A Study on the Mechanism of Hypericism

Abstract

Hypericism 현상의 광화학적 근거를 확립하기 위하여 hypericin의 광증감성질의 메커니즘을 밝히는 실험으로 (a) hypericin의 광증감작용, (b) 광반응의 용매동위원소효과 (c) superoxide에 의한 3가철이온의 환원, (d) enzyme의 activity에 미치는 광효과 등을 용액속에서 조사하였다.

이러한 실험에서 얻은 결과로 hypericin의 광화학작용은 광전자전달로 생성될 수 있는 superoxide anion이 관련됨을 알았다.

In order to establish the photochemical basis of hypericism, the following experiments were aimed at elucidating the mechanism of photosensitization by hypericin in solution;(a) photosensitizing property of hypericin, (b) solvent isotope effect on photodynamic action, (c) reduction of ferric ion by syperoxide, and (d) effects of light on the activity of alkaline phosphatase in the presence of hypericin.

The photodynamic actions of hypericin involving superoxide anions, which can be produced from photoelctron transfer processes are in goods agreement with these experimental results obtained.

In order to establish the photochemical basis of hypericism, the following experiments were aimed at elucidating the mechanism of photosensitization by hypericin in solution;(a) photosensitizing property of hypericin, (b) solvent isotope effect on photodynamic action, (c) reduction of ferric ion by syperoxide, and (d) effects of light on the activity of alkaline phosphatase in the presence of hypericin.

The photodynamic actions of hypericin involving superoxide anions, which can be produced from photoelctron transfer processes are in goods agreement with these experimental results obtained.