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Effects of Tenofovir vs Entecavir on Risk of Hepatocellular Carcinoma in Patients With Chronic HBV Infection: A Systematic Review and Meta-analysis

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Abstract
Background & Aims: Tenofovir disoproxil fumarate (TDF) and entecavir are recommended as first-line treatments for chronic hepatitis B virus (HBV) infection. However, there is debate over the comparative effectiveness of these drugs in preventing hepatocellular carcinoma (HCC). We performed a systematic review and meta-analysis of the effectiveness of TDF vs entecavir in reducing the incidence of HCC among patients with chronic HBV infection. Methods: We performed a systematic review of the MEDLINE, EMBASE, Web of Science, and Cochrane Library from 2010 through 2019 for full-text articles and conference abstracts on studies of effects of TDF vs entecavir in patients with HBV infection. Extracted data were analyzed with the random-effects model. Potential sources of heterogeneity were investigated using sensitivity, meta-regression, and subgroup analyses. Results: Our final analysis comprised 15 studies (61,787 patients; 16,101 patients given TDF and 45,686 given entecavir). TDF treatment was associated with a significantly lower risk of HCC than entecavir (hazard ratio, 0.80; 95% CI, 0.69?0.93; P =.003; I
Author(s)
최원묵최종기임영석
Issued Date
2021
Type
Article
Keyword
hepatocellular carcinomahepatitis b
DOI
10.1016/j.cgh.2020.05.008
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7035
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2404047789&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Effects%20of%20Tenofovir%20vs%20Entecavir%20on%20Risk%20of%20Hepatocellular%20Carcinoma%20in%20Patients%20With%20Chronic%20HBV%20Infection:%20A%20Systematic%20Review%20and%20Meta-analysis&offset=0&pcAvailability=true
Publisher
Clinical Gastroenterology and Hepatology
Location
미국
Language
영어
ISSN
1542-3565
Citation Volume
19
Citation Number
2
Citation Start Page
246
Citation End Page
258.e9
Appears in Collections:
Medicine > Medicine
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