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Prognostic Factor and Clinical Outcome in Stage III Non-Small Cell Lung Cancer: A Study Based on Real-World Clinical Data in the Korean Population

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Abstract
Purpose: The optimal treatment for patients with stage III non-small cell lung cancer (NSCLC) remains controversial. This study aimed to investigate prognostic factors and clinical outcome in stage III NSCLC using real-world clinical data in the Korean population.

Materials and methods: Among 8,110 patients with lung cancer selected from 52 hospitals in Korea during 2014-2016, only patients with stage III NSCLC were recruited and analyzed. A standardized protocol was used to collect clinical information and cox proportional hazards models were used to identify risk factors for mortality.

Results: A total of 1,383 patients (46.5% had squamous cell carcinoma and 40.9% had adenocarcinoma) with stage III NSCLC were enrolled, and their median age was 70 years. Regarding clinical stage, 548 patients (39.6%) had stage IIIA, 517 (37.4%) had stage IIIB, and 318 (23.0%) had stage IIIC. Pertaining to the initial treatment method, the surgery group (median survival period: 36 months) showed better survival outcomes than the non-surgical treatment group (median survival period: 18 months, p=0.001) in patients with stage IIIA. Moreover, among patients with stage IIIB and stage IIIC, those who received concurrent chemotherapy and radiation therapy (CCRT, median survival period: 24 months) showed better survival outcomes than those who received chemotherapy (median survival period: 11 months), or radiation therapy (median survival period: 10 months, p<0.001).

Conclusion: While surgery might be feasible as the initial treatment option in patients with stage IIIA NSCLC, CCRT showed a beneficial role in patients with stage IIIB and IIIC NSCLC.

Keywords: Concurrent chemotherapy and radiation therapy; Korea; Lung neoplasms; Surgery.
Author(s)
김형렬김호철송시열이재철최창민Korean Association for Lung CaWonjun Ji
Issued Date
2021
Type
Article
Keyword
Concurrent chemotherapy and radiation therapyKoreaLung neoplasmsSurgery
DOI
10.4143/crt.2020.1350
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7172
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9870954&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Prognostic%20Factor%20and%20Clinical%20Outcome%20in%20Stage%20III%20Non-Small%20Cell%20Lung%20Cancer:%20A%20Study%20Based%20on%20Real-World%20Clinical%20Data%20in%20the%20Korean%20Population&amp;offset=0&amp;pcAvailability=true
Publisher
CANCER RESEARCH AND TREATMENT
Location
대한민국
Language
한국어
ISSN
1598-2998
Citation Volume
53
Citation Number
4
Citation Start Page
1033
Citation End Page
1041
Appears in Collections:
Medicine > Medicine
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