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Mucin1 and Mucin16: Therapeutic Targets for Cancer Therapy

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Abstract
The mucin (MUC) family is a group of highly glycosylated macromolecules that are abundantly expressed in mammalian epithelial cells. MUC proteins contribute to the formation of the mucus barrier and thus have protective functions against infection. Interestingly, some MUC proteins are aberrantly expressed in cancer cells and are involved in cancer development and progression, including cell growth, proliferation, the inhibition of apoptosis, chemoresistance, metabolic reprogramming, and immune evasion. With their unique biological and structural features, MUC proteins have been considered promising therapeutic targets and also biomarkers for human cancer. In this review, we discuss the biological roles of the transmembrane mucins MUC1 and MUC16 in the context of hallmarks of cancer and current efforts to develop MUC1- and MUC16-targeted therapies.
Author(s)
박윤이동희최승현진형승
Issued Date
2021
Type
Article
Keyword
mucinMUC1MUC16immunotherapycancer vaccineCAR (chimeric antigen receptor)ADC (antibody-drug conjugate)
DOI
10.3390/ph14101053
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7321
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_800b039c41fc4000a3e674e919187830&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Mucin1%20and%20Mucin16:%20Therapeutic%20Targets%20for%20Cancer%20Therapy&offset=0&pcAvailability=true
Publisher
Pharmaceuticals
Location
스위스
Language
영어
ISSN
1424-8247
Citation Volume
14
Citation Number
10
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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