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A propensity score-matched comparison of recurrence outcomes after immediate implant vs autologous flap reconstruction in patients receiving neoadjuvant chemotherapy for breast cancer

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Abstract
Purpose We compared oncologic outcomes between breast cancer patients who underwent immediate implant-based breast reconstruction (IBBR) and those who underwent autologous flap reconstruction (AFR) after neoadjuvant chemotherapy (NACT). Methods The study group comprised 536 patients with primary breast cancer who underwent NACT followed by immediate IBBR or AFR. After propensity score matching, 138 patients in the IBBR group and 276 patients in the AFR group were selected for comparisons of locoregional recurrence-free survival (LRRFS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and breast cancer-specific survival (BCSS). Results No significant differences were observed between the matched groups in locoregional recurrence rates (IBBR vs. AFR: 12.3% vs. 12%; P = 0.915) and distant metastasis (13% vs. 17%; P = 0.293). There was also no significant difference between the groups in LRRFS (P = 0.956), DFS (P = 0.606), DMFS (P = 0.283), or BCSS (P = 0.121). The 5- and 10-year LRRFS rates were 87.6% and 85.9% in the IBBR group, and 87.7% and 86.1% in the AFR group; the 5- and 10-year DFS rates were 79% and 77.5% in the IBBR group, and 77% and 75% in the AFR group; the 5- and 10-year DMFS rates were 85.9% and 85.9% in the IBBR group, and 83.2% and 81.8% in the AFR group; and the 5- and 10-year BCSS rates were 97.8% and 91.3% in the IBBR group, and 91.8% and 86% in the AFR group, respectively. Conclusions In this propensity score-matched analysis of oncologic outcomes in breast cancer patients who underwent immediate reconstruction after NACT, no significant differences were observed between the IBBR and AFR groups.
Author(s)
고범석공경엽김성배김지선김학희김희정손병호안세현엄진섭이새별이종원정일용정재호한현호Zhen Yu Wu
Issued Date
2021
Type
Article
Keyword
Adjuvant treatmentBreast cancerCancerCancer patientsClinical TrialComparative analysisMammaplastyMedicineMedicine & Public HealthMetastasisOncologyOncologyExperimentalPatient outcomesResearch
DOI
10.1007/s10549-021-06114-w
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7562
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2503445143&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,A%20propensity%20score-matched%20comparison%20of%20recurrence%20outcomes%20after%20immediate%20implant%20vs%20autologous%20flap%20reconstruction%20in%20patients%20receiving%20neoadjuvant%20chemotherapy%20for%20breast%20cancer&offset=0&pcAvailability=true
Publisher
BREAST CANCER RESEARCH AND TREATMENT
Location
네덜란드
Language
영어
ISSN
0167-6806
Citation Volume
187
Citation Number
2
Citation Start Page
417
Citation End Page
425
Appears in Collections:
Medicine > Medicine
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