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Prenatal heavy metal exposures and atopic dermatitis with gender difference in 6-month-old infants using multipollutant analysis

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Abstract
Background: Prenatal exposure to heavy metals during critical developmental phases has been implicated in allergic phenotypes. However, few studies have been conducted on the gender-specific association of prenatal heavy metal exposure with atopic dermatitis (AD) in infants. Objective: To examine the gender-specific association of prenatal exposure to multiple heavy metals with AD incidence in 6-month-old infants using data from the Mothers and Children's Environmental Health (MOCEH). Methods: We evaluated 738 mother-child pairs from the MOCEH study, an ongoing prospective birth cohort. The concentrations of three heavy metals (lead, mercury and cadmium) in maternal blood samples were measured during early and late pregnancy. Each quartile of heavy metal concentration was used to consider the possible nonlinear association with AD. For assessing the multi-pollutant model, we constructed the multivariate regression model including all three heavy metals at both early and late pregnancy. Further, the group Lasso model was used to perform the variable selection with categorized exposures and assess the effect of multiple pollutants including their pairwise interactions. Results: A total of 200 incident cases of AD were diagnosed in 6-month-old infants. In the multivariate regression model of the boy group, adjusted odds ratios comparing the second, third and fourth quartile of lead exposure in boys with the first quartile were 1.83 (95% CI: 1.00, 3.38), 1.04 (0.91, 3.32) and 2.40 (1.18, 4.90), respectively. However, the only second quartile of lead exposure compared to first quartile was significantly associated with AD in girls. In addition, the results of the group Lasso model were similar with the results of multivariate regression model. Conclusion: The results suggest that lead exposure in late pregnancy increases risk of AD in 6-month-old boys although the strength of association is weak. Further studies are needed to confirm the susceptibility window and gender differences in lead-induced AD.
Author(s)
이슬비박성균박혜숙이우주권정현홍윤철하미나김양호이보은하은희
Issued Date
2021
Type
Article
Keyword
AnalysisAtopic dermatitisChildAtopic - chemically inducedAtopic - epidemiologyFemaleHeavy metalHumansInfantInfantsMaleMaternal Exposure - adverse effectsHeavy - toxicityMultiple pollutantsPregnancyPregnant womenPrenatal exposurePrenatal Exposure Delayed Effects - chemicallyinducedPrenatal Exposure Delayed Effects - epidemiologyProspective cohortProspective StudiesSex Characteristics
DOI
10.1016/j.envres.2021.110865
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7703
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_gale_infotracacademiconefile_A655280827&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Prenatal%20heavy%20metal%20exposures%20and%20atopic%20dermatitis%20with%20gender%20difference%20in%206-month-old%20infants%20using%20multipollutant%20analysis&offset=0&pcAvailability=true
Publisher
ENVIRONMENTAL RESEARCH
Location
네덜란드
Language
영어
ISSN
0013-9351
Citation Volume
195
Citation Number
1
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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