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Undervaluation of Radiotherapy for Gross Desmoid Tumors: The Need for Absolute Volume Assessment

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Abstract
Background/Aim: To compare absolute volume (AV) assessment according to Response Evaluation Criteria in Solid Tumors (RECIST) for the response evaluation of desmoid tumors (DTs) treated with radiotherapy. Patients and Methods: Eighteen patients with DTs >= 3 cm in size were included. Results: The median follow-up duration was 78.0 months. Five patients achieved a complete response according to RECIST, seven reached a partial response (PR), and one eventually exhibited progression. The overall response rate was 61%, the median time to PR was 8.0 months. Six patients achieved stable disease, although three developed progressions. Of the six patients with a PR, the median change in maximum diameter was -46%, and the median change in maximum volume was -84%. Three patients could have been diagnosed with progression at least 6 months earlier if the AV increment was considered. Conclusion: An AV assessment is essential for an accurate response assessment of DTs and radiotherapy seems feasible as a first-line treatment for DTs.
Author(s)
김연주송시열김완림이종석안진희김정은정혜원정성윤최은경
Issued Date
2021
Type
Article
Keyword
absolute volumeDesmoid tumorradiotherapyRECISTresponse assessment
DOI
10.21873/invivo.12437
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7934
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8193310&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Undervaluation%20of%20Radiotherapy%20for%20Gross%20Desmoid%20Tumors:%20The%20Need%20for%20Absolute%20Volume%20Assessment&offset=0&pcAvailability=true
Publisher
IN VIVO
Location
그리스
Language
영어
ISSN
0258-851X
Citation Volume
35
Citation Number
3
Citation Start Page
1777
Citation End Page
1784
Appears in Collections:
Medicine > Medicine
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