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Acetazolamide-eluting biodegradable tubular stent prevents pancreaticojejunal anastomotic leakage

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Abstract
Postoperative pancreatic fistula at the early stage can lead to auto-digestion, which may delay the recovery of the pancreaticojejunal (PJ) anastomosis. The efficacy and safety of an acetazolamide-eluting biodegradable tubular stent (AZ-BTS) for the prevention of self-digestion and intra-abdominal inflammatory diseases caused by pancreatic juice leakage after PJ anastomosis in a porcine model were investigated. The AZ-BTS was successfully fabricated using a multiple dip-coating process. Then, the drug amount and release profile were analyzed. The therapeutic effects of AZ were examined in vitro using two kinds of pancreatic cancer cell lines, AsPC-1 and PANC-1. The efficacy of AZ-BTS was assessed in a porcine PJ leakage model, with animals were each assigned to a leakage group, a BTS group and an AZ-BTS group. The overall mortality rates in these three groups were 44.4%, 16.6%, and 0%, respectively. Mean alpha-amylase concentrations were significantly higher in the leakage and BTS groups than in the AZ-BTS group on day 2-5 (p < 0.05 each all). The luminal diameters and areas of the pancreatic duct were significantly larger in the leakage group than in the BTS and AZ-BTS groups (p < 0.05 each all). These findings indicate that AZ-BTS can significantly suppress intra-abdominal inflammatory diseases caused by pancreatic juice leakage and also prevent late stricture formation at the PJ anastomotic site in a porcine model.
Author(s)
박정훈박지은박예종강전민유대성경정수장종권황창모심인경송호영양수근김송철
Issued Date
2021
Type
Article
Keyword
AcetazolamideAnalysisInflammationPancreasPancreatic cancerPancreaticojejunal anastomosisPostoperative pancreatic fistulaStent (Surgery)Stents
DOI
10.1016/j.jconrel.2021.06.010
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7987
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2540512951&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Acetazolamide-eluting%20biodegradable%20tubular%20stent%20prevents%20pancreaticojejunal%20anastomotic%20leakage&amp;offset=0&amp;pcAvailability=true
Publisher
JOURNAL OF CONTROLLED RELEASE
Location
미국
Language
영어
ISSN
0168-3659
Citation Volume
335
Citation Number
1
Citation Start Page
650
Citation End Page
659
Appears in Collections:
Medicine > Medicine
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