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Long-term effect of a 24-week multicomponent intervention on physical performance and frailty in community-dwelling older adults

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Abstract
Introduction: Multicomponent interventions improve physical function and frailty in older adults, but their long-term benefit remains uncertain.
Methods: This prospective non-randomised study was conducted in 383 older Koreans (mean age, 76.8 years; female 72.3%) who were living alone or receiving medical aid. Of these, 187 individuals chose to receive a 24-week intervention that consisted of group exercise, nutritional supplements, depression management, deprescribing and home hazard reduction. The remaining 196 individuals received usual care. We compared the short physical performance battery (SPPB) score (0?12 points), frailty phenotype scale (0?5 points) and deficit-accumulation frailty index (0?1) at baseline, 6, 18 and 30 months.
Results: After 1:1 propensity score matching (n?=?117 per group), the mean SPPB scores for the intervention and comparison groups were 7.6 versus 7.6 at baseline, 10.7 versus 7.1 at 6 months (mean difference, 3.5; 95% confidence interval [CI], 2.8?4.2), 9.1 versus 7.8 at 18 months (1.3; 95% CI, 0.6?2.0) and 8.6 versus 7.5 at 30 months (1.1; 95% CI, 0.4?1.8). The intervention group had lower frailty phenotype scale (1.1 versus 1.8; difference, ?0.7; 95% CI ?1.0 to ?0.3) and frailty index (0.22 versus 0.27; difference, ?0.04; ?0.06 to ?0.02) at 6 months, but similar scores at 18 and 30 months. The 30-month mean institutionalisation-free survival time was 28.5 months in the intervention group versus 23.3 months in the comparison group (difference, 5.2 months; 95% CI, 3.1?7.4).
Conclusions: The 24-week multicomponent intervention showed sustained improvement in physical function, temporary reduction in frailty and longer institutionalisation-free survival over 30 months.
Author(s)
박찬미이은주이혜연장일영정희원Dae Hyun KimGahee OhJack M Guralnik
Issued Date
2021
Type
Article
Keyword
clinical trialcommunity health servicesfrailtymortalityphysical fitnessolder people
DOI
10.1093/ageing/afab149
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8105
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2558451185&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Long-term%20effect%20of%20a%2024-week%20multicomponent%20intervention%20on%20physical%20performance%20and%20frailty%20in%20community-dwelling%20older%20adults&offset=0&pcAvailability=true
Publisher
AGE AND AGEING
Location
영국
Language
영어
ISSN
0002-0729
Citation Volume
50
Citation Number
6
Citation Start Page
2157
Citation End Page
2166
Appears in Collections:
Medicine > Medicine
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