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Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population

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Abstract
Background/Aims: Recent evidence suggests an association between allergic sensitization and metabolic markers. However, this association has rarely been examined in the elderly. Retinol-binding protein-4 (RBP-4) is a recently identified adipokine that acts on the muscle and liver affecting insulin sensitivity. We evaluated the association between metabolic parameters and allergic sensitization in the elderly.

Methods: We analysed the database of the Korean Longitudinal Study on Health and Aging cohort study conducted during 2005 to 2006. Atopy was identified by inhalant allergen skin prick test. Metabolic conditions were assessed using anthropometric indices and serum biomarkers such as fasting glucose, lipid, adiponectin, and RBP-4.

Results: Among the 854 elderly subjects, 17.2% had atopy. Plasma RBP-4 levels were significantly higher in the atopic elderly than nonatopic elderly (p = 0.003). When RBP-4 percentiles were categorized as under three groups, the prevalence of atopy and current rhinitis increased significantly with percentiles of RBP-4 levels (p = 0.019 and p = 0.007, respectively). Log RBP-4 was associated with atopy (odds ratio [OR], 4.10; p = 0.009) and current rhinitis (OR, 2.73; p = 0.014), but not with current asthma (OR, 1.17; p = 0.824). Higher RBP-4 level in atopic elderly was also observed in current rhinitis patients. Atopy, but not current rhinitis, showed significant relationships with log RBP-4 levels in multivariate analyses adjusted for other metabolic markers including body mass index.

Conclusions: RBP-4 positively associated with atopy in the general elderly population irrespective of other metabolic markers.
Author(s)
김기웅김병근김새훈김주영서보미송우정장윤석장학
Issued Date
2021
Type
Article
Keyword
AtopyElderlyRetinol-binding protein-4
DOI
10.3904/kjim.2019.348
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8141
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_kiss_primary_3860333&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Retinol-binding%20protein-4%20was%20associated%20with%20sensitization%20to%20inhalant%20allergens%20in%20the%20elderly%20population&offset=0&pcAvailability=true
Publisher
KOREAN JOURNAL OF INTERNAL MEDICINE
Location
대한민국
Language
한국어
ISSN
1226-3303
Citation Volume
36
Citation Number
2
Citation Start Page
447
Citation End Page
455
Appears in Collections:
Medicine > Medicine
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