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연령에 따른 저밀도지단백-콜레스테롤과 죽상경화성 심혈관계질환의 연관성 연구

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Abstract
Background: It remains undetermined if the relationship between LDL cholesterol (LDL-C) and atherosclerotic cardiovascular disease (ASCVD) changes with age. Thus, this study aimed to investigate whether the association of LDL-C and ASCVD may be affected by the subject’s age.

Methods: Data from the Korean National Health Insurance Service-National Health Screening Cohort were analyzed. Individuals previously diagnosed with cardiovascular disease (CVD) or taking lipid-lowering drugs were excluded. Age-specific association between LDL-C and ASCVD was calculated using adjusted Cox proportional hazards models.

Results: During a median follow-up of 6.44 years, ASCVD developed in 8,996 (3.2%) among 285,119 Korean adults. All age groups showed positive associations between LDL-C and ASCVD risk with a statistical significance from LDL-C of ≥ 160 mg/dL. The risk of ASCVD did not significantly differ between the age groups (P for interaction = 0.62). With a reference to the ASCVD risk in the group of LDL-C 70-99 mg/dL, the ASCVD risk in the group of highest LDL-C (≥190 mg/dL) was similar between the subjects of age <50 and those of age 70 years (adjusted hazard ratio [aHR], 1.90 [95% confidence interval (CI), 1.52-2.38] vs. 1.86 [95% CI, 1.30-2.68]). Consistently, the subgroup analysis in subjects with type 2 diabetes exhibited no difference in the association of LDL-C and ASCVD between different age groups (P for interaction = 0.31).

Conclusions: A nationwide population-based cohort study of individuals who had no prior CVD history and were not on lipid-lowering drugs, demonstrated that elderly Korean subjects (>70 years of age) still presented increased ASCVD risk if they had higher LDL-C at baseline. Thus, the association of LDL-C and ASCVD in elderly Korean population did not significantly differ from that in the younger groups. These findings support the importance of managing LDL-C for the purpose of primary prevention of ASCVD in the elderly population.
Author(s)
정한나
Issued Date
2022
Awarded Date
2022-02
Type
dissertation
Keyword
저밀도지단백-콜레스테롤죽상경화성 심혈관계질환연령
URI
https://oak.ulsan.ac.kr/handle/2021.oak/10033
http://ulsan.dcollection.net/common/orgView/200000595140
Alternative Author(s)
Jung, Han Na
Affiliation
울산대학교
Department
일반대학원 의학과의학전공
Advisor
김민선
Degree
Master
Publisher
울산대학교 일반대학원 의학과의학전공
Language
eng
Rights
울산대학교 논문은 저작권에 의해 보호 받습니다.
Appears in Collections:
Medicine > 1. Theses (Master)
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