표적 약물 전달을 위한 췌장 성상세포 유래 엑소좀의 표면 단백질 공학

Abstract

Exosomes are small vesicles that carry biomolecules, such as proteins, microRNAs, and metabolites, and have great potential as therapeutic delivery vehicles. Chemotherapeutic agents used in cancer therapy can cause severe side effects, making the need for improved selectivity and stability of these drugs imperative. Exosomes provide an attractive platform for loading different types of therapeutics, and their surface can be modified by specific surface proteins that increase their local concentration at target cells or disease sites, leading to improved therapeutic outcomes with reduced toxicity.