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Aryl Hydrocarbon Receptor Antagonists Alleviate Acute Hepatic Ischemia-Reperfusion Injury

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Abstract
Aryl hydrocarbon receptors (AhRs) are important mediators of ischemic injury in the brain. Furthermore, pharmacological inhibition of AhR activation after ischemia attenuates cerebral ischemia-reperfusion (IR) injury. Here, we investigated whether administration of an AhR antagonist after ischemia was effective in ameliorating hepatic IR injury. Therefore, a 70% partial hepatic IR injury (45-min ischemia and 24-h reperfusion) was induced in rats, and 6,2',4'-trimethoxyflavone (TMF; 5 mg/kg) was administered to them intraperitoneally 10 min after ischemia. Hepatic IR injury was assed using serum samples, magnetic resonance imaging-based liver function indices, and liver samples. TMF-treated rats showed significantly lower relative enhancement (RE) values and serum alanine aminotransferase (ALT) and aspartate aminotransferase levels than control rats 3 h after reperfusion. Additionally, 24 h after reperfusion, TMF-treated rats had significantly lower RE values, ΔT1 values, serum ALT levels, and necrotic area percentage than rats of the control group. Moreover, the expression of the apoptosis-related proteins Bax and cleaved caspase- 3 was significantly lower in TMF-treated rats than in control rats. This study showed that AhR activation inhibition after ischemia ameliorates IR-induced liver injury in rats. Key words: Aryl hydrocarbon receptor, hepatic ischemia-reperfusion injury, magnetic resonance imaging
Author(s)
권재임
Issued Date
2024
Awarded Date
2024-02
Type
Dissertation
URI
https://oak.ulsan.ac.kr/handle/2021.oak/13141
http://ulsan.dcollection.net/common/orgView/200000728541
Alternative Author(s)
Kwon Jae-Im
Affiliation
울산대학교
Department
일반대학원 의과학과 의과학전공
Advisor
Dong Cheol Woo
Degree
Doctor
Publisher
울산대학교 일반대학원 의과학과 의과학전공
Language
eng
Rights
울산대학교 논문은 저작권에 의해 보호받습니다.
Appears in Collections:
Medical Science > 2. Theses (Ph.D)
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