고도 비만 환자에서 위소매절제술 후 성별ㆍ연령군별 체중변화 및 대사 지표 추적에 대한 12개월 후향적 코호트 연구

Abstract

Background: Bariatric surgery has beneficial effects on weight loss and metabolic profiles in morbidly obese patients. A 12-month retrospective cohort study was performed to investigate changes in body weight according to sex, age, and metabolic parameters among Korean morbidly obese patients after undergoing sleeve gastrectomy.

Methods: We included 58 patients with an initial body mass index (BMI) of 35 kg/m2 or more, or a BMI of 30 kg/m2 with metabolic comorbidities, who underwent laparoscopic sleeve gastrectomy. We collected body weight and biochemistry data pre- and post-surgery and analyzed longitudinal changes of body weight and metabolic parameters.

Results: The mean preoperative and postoperative weights were 124.77 kg and 92.77 kg (pre- and at 12 months, respectively) in males and 99.21 kg and 75.29 kg in females, respectively (P<0.0001). The mean preoperative and postoperative BMIs were 39.57 kg/m2 and 29.39 kg/m2 in males, and 38.20 kg/m2 and 29.02 kg/m2 in females, respectively (P<0.0001). There was no difference in percent (%) BMI change between males and females. However, younger patients aged <40 years showed a higher % BMI change post-op at 2 weeks, 3 months, 6 months, 9 months, and 12 months than those aged ≥40 years. Metabolic parameters were significantly improved after sleeve gastrectomy.

Conclusion: In Korean morbidly obese patients, approximately 25% weight reduction and metabolic improvement were achieved at 12 months after sleeve gastrectomy. Increased percentages of weight change were observed in younger patients. Large-scaled, prospective studies are needed to verify the long-term effectiveness of bariatric surgery in Korean morbidly obese patients.