약물 관련 악골괴사와 연관된 위험인자와 골밀도에 관한 연구

Abstract

To examine risk factors of MRONJ and compare whether there is a difference in BMD value depending on the duration of administration, method of administration, and occurrence of MRONJ. We selected 53 patients who were diagnosed with MRONJ at the Ulsan University Hospital and underwent surgery between January 2011 and May 2021. The risk factors are age, sex, systemic disease, location, administration methods, type of drug, duration, local factors and stage. 19 patients, especially those who were diagnosed with MRONJ and underwent BMD, were compared with BMD in femur and lumbar areas according to duration, administration methods. There were many women in all age groups, with 18 in their 70s. There were about twice as many mandibles as the maxilla. It was significantly higher when the IV BPs was administered in cancer patients, and significantly higher when the oral BPs was administered in osteoporosis patients. There was a significant difference between each period in patients taking oral BPs, and the incidence of MRONJ was high when taking them for more than 4 years. There were 35 patients who developed into MRONJ after dentoalveolar surgery. There were significant differences in femur and lumbar BMD, T-scores by administration method, with lumbar BMD, T-scores being significantly higher in the IV BP group compared to the oral BP group.