Fetal growth rather than prematurity determines lung function in children with asthma
- Alternative Title
- Fetal growth rather than prematurity determines lung function in children with asthma
- Abstract
- Background and objective: Preterm birth or fetal growth has been associated with reduced lung function and asthma during childhood in the general population. We aimed to elucidate whether prematurity or fetal growth has a significant influence on lung function or symptoms in children with stable asthma.
Methods: We included children with stable asthma who participated in the Korean childhood Asthma Study cohort. Asthma symptoms were determined by asthma control test (ACT). Percent predicted values of pre- and post-bronchodilator (BD) lung function including forced expiratory volume in 1 second (FEV1 ), forced vital capacity (FVC), and forced expiratory flow at 25%-75% of FVC (FEF25%-75% ) were measured. Lung function and symptoms were compared according to the history of preterm birth and birth weight (BW) for gestational age (GA).
Results: The study population consisted of 566 children (age range: 5-18 years). There were no significant differences in lung function and ACT between preterm and term subjects. We observed no significant difference in ACT but significant differences were observed in pre- and post-BD FEV1 , pre- and post-BD FVC, and post-BD FEF25%-75% according to BW for GA in total subjects. Two-way ANOVA revealed that BW for GA rather than prematurity was a significant determining factor for pre- and post-BD lung function. After regression analysis, BW for GA was still a significant determining factor of pre- and post-BD FEV1 and pre- and post-BD FEF25%-75% .
Conclusion: Fetal growth rather than prematurity appears to have a significant effect on lung function in children with stable asthma.
- Author(s)
- Hwan Soo Kim; Seung Won Lee; Jin Tack Kim; Jung Hoon Kim; Dae Hyun Lim; Woo Kyung Kim; Dae Jin Song; Young Yoo; Dong In Suh; Hey Sung Baek; Meeyong Shin; Ji Won Kwon; Gwang Cheon Jang; Hyeon-Jong Yang; Eun Lee; Ju Hee Seo; Sung Il Woo; Hyung Young Kim; Youn Ho Shin; Ju Suk Lee; Sungsu Jung; Nang Kyeong Lee; Jinho Yu
- Issued Date
- 2023
- Type
- Article
- Keyword
- asthma; fetal growth; lung function; prematurity
- DOI
- 10.1111/resp.14528
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/16723
- Publisher
- RESPIROLOGY
- Language
- 영어
- ISSN
- 1323-7799
- Citation Volume
- 28
- Citation Number
- 9
- Citation Start Page
- 841
- Citation End Page
- 850
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Appears in Collections:
- Medicine > Nursing
- 공개 및 라이선스
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