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Fetal growth rather than prematurity determines lung function in children with asthma

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Alternative Title
Fetal growth rather than prematurity determines lung function in children with asthma
Abstract
Background and objective: Preterm birth or fetal growth has been associated with reduced lung function and asthma during childhood in the general population. We aimed to elucidate whether prematurity or fetal growth has a significant influence on lung function or symptoms in children with stable asthma.

Methods: We included children with stable asthma who participated in the Korean childhood Asthma Study cohort. Asthma symptoms were determined by asthma control test (ACT). Percent predicted values of pre- and post-bronchodilator (BD) lung function including forced expiratory volume in 1 second (FEV1 ), forced vital capacity (FVC), and forced expiratory flow at 25%-75% of FVC (FEF25%-75% ) were measured. Lung function and symptoms were compared according to the history of preterm birth and birth weight (BW) for gestational age (GA).

Results: The study population consisted of 566 children (age range: 5-18 years). There were no significant differences in lung function and ACT between preterm and term subjects. We observed no significant difference in ACT but significant differences were observed in pre- and post-BD FEV1 , pre- and post-BD FVC, and post-BD FEF25%-75% according to BW for GA in total subjects. Two-way ANOVA revealed that BW for GA rather than prematurity was a significant determining factor for pre- and post-BD lung function. After regression analysis, BW for GA was still a significant determining factor of pre- and post-BD FEV1 and pre- and post-BD FEF25%-75% .

Conclusion: Fetal growth rather than prematurity appears to have a significant effect on lung function in children with stable asthma.
Author(s)
Hwan Soo KimSeung Won LeeJin Tack KimJung Hoon KimDae Hyun LimWoo Kyung KimDae Jin SongYoung YooDong In SuhHey Sung BaekMeeyong ShinJi Won KwonGwang Cheon JangHyeon-Jong YangEun LeeJu Hee SeoSung Il WooHyung Young KimYoun Ho ShinJu Suk LeeSungsu JungNang Kyeong LeeJinho Yu
Issued Date
2023
Type
Article
Keyword
asthmafetal growthlung functionprematurity
DOI
10.1111/resp.14528
URI
https://oak.ulsan.ac.kr/handle/2021.oak/16723
Publisher
RESPIROLOGY
Language
영어
ISSN
1323-7799
Citation Volume
28
Citation Number
9
Citation Start Page
841
Citation End Page
850
Appears in Collections:
Medicine > Nursing
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