Survival outcomes of breast cancer patients with recurrence after surgery according to period and subtype
- Alternative Title
- Survival outcomes of breast cancer patients with recurrence after surgery according to period and subtype
- Abstract
- Purpose: To analyze and compare the survival rates of recurrent breast cancer patients in Korea between two periods (period I: 2000-2007; period II: 2008-2013) and to identify the factors associated with outcomes and changes over time in the duration of survival after recurrence.
Methods: We retrospectively analyzed 2,407 patients who had recurrent breast cancer with treated between January 2000 and December 2013 and divided them into two periods according to the year of recurrence. We reviewed the age at diagnosis, clinical manifestations, pathology report, surgical methods, types of adjuvant treatment, type of recurrence, and follow-up period.
Results: The median follow-up was 30.6 months (range, 0-223.4) from the time of relapse, and the median survival time was 42.3 months. Survival after recurrence (SAR) significantly improved from 38.0 months in period I to 49.7 months in period II (p < 0.001). In the analysis performed according to the hormone receptor and HER2 status subtypes, all subtypes except the triple-negative subtype showed higher SAR in period II than period I. Age at diagnosis, tumor stage, and treatment after recurrence were significantly correlated with survival outcomes.
Conclusion: The survival outcomes of Korean patients with breast cancer after the first recurrence have improved in Korea. Such improvements may be attributed to advances in treatment.
- Author(s)
- Young-Jin Lee; Tae-Kyung Yoo; Jisun Kim; Il Yong Chung; Beom Seok Ko; Hee Jeong Kim; Jong Won Lee; Byung Ho Son; Sei-Hyun Ahn; Sae Byul Lee
- Issued Date
- 2023
- Type
- Article
- Keyword
- Medicine and health sciences; Oncology; Cancer treatment; Cancers and neoplasms; Breast tumors; Breast cancer; Pharmaceutics; Drug therapy; Hormonal therapy; Biology and life sciences; Biochemistry; Hormones; Diagnostic medicine; Cancer detection and diagnosis; Radiation therapy; Clinical medicine; Clinical oncology; Prognosis; Cancer chemotherapy; Chemotherapy
- DOI
- 10.1371/journal.pone.0284460
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/16845
- Publisher
- PLoS One
- Language
- 영어
- ISSN
- 1932-6203
- Citation Volume
- 18
- Citation Number
- 7
- Citation Start Page
- 1
- Citation End Page
- 15
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Appears in Collections:
- Medicine > Nursing
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