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Survival outcomes of breast cancer patients with recurrence after surgery according to period and subtype

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Alternative Title
Survival outcomes of breast cancer patients with recurrence after surgery according to period and subtype
Abstract
Purpose: To analyze and compare the survival rates of recurrent breast cancer patients in Korea between two periods (period I: 2000-2007; period II: 2008-2013) and to identify the factors associated with outcomes and changes over time in the duration of survival after recurrence.

Methods: We retrospectively analyzed 2,407 patients who had recurrent breast cancer with treated between January 2000 and December 2013 and divided them into two periods according to the year of recurrence. We reviewed the age at diagnosis, clinical manifestations, pathology report, surgical methods, types of adjuvant treatment, type of recurrence, and follow-up period.

Results: The median follow-up was 30.6 months (range, 0-223.4) from the time of relapse, and the median survival time was 42.3 months. Survival after recurrence (SAR) significantly improved from 38.0 months in period I to 49.7 months in period II (p < 0.001). In the analysis performed according to the hormone receptor and HER2 status subtypes, all subtypes except the triple-negative subtype showed higher SAR in period II than period I. Age at diagnosis, tumor stage, and treatment after recurrence were significantly correlated with survival outcomes.

Conclusion: The survival outcomes of Korean patients with breast cancer after the first recurrence have improved in Korea. Such improvements may be attributed to advances in treatment.
Author(s)
Young-Jin LeeTae-Kyung YooJisun KimIl Yong ChungBeom Seok KoHee Jeong KimJong Won LeeByung Ho SonSei-Hyun AhnSae Byul Lee
Issued Date
2023
Type
Article
Keyword
Medicine and health sciencesOncologyCancer treatmentCancers and neoplasmsBreast tumorsBreast cancerPharmaceuticsDrug therapyHormonal therapyBiology and life sciencesBiochemistryHormonesDiagnostic medicineCancer detection and diagnosisRadiation therapyClinical medicineClinical oncologyPrognosisCancer chemotherapyChemotherapy
DOI
10.1371/journal.pone.0284460
URI
https://oak.ulsan.ac.kr/handle/2021.oak/16845
Publisher
PLoS One
Language
영어
ISSN
1932-6203
Citation Volume
18
Citation Number
7
Citation Start Page
1
Citation End Page
15
Appears in Collections:
Medicine > Nursing
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