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Photodynamic treatment of acute vascular occlusion by using an iron-nitrosyl complex

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Abstract
Retinal vascular occlusion (RVO) is a common cause of visual impairment. Although several approaches, including vasodilators, have been explored to treat retinal vascular occlusion, there is no proper
method to treat this obstruction today. We report a strategy that aims to pierce clogged blood vessels with a spatiotemporally controllable nitric oxide transporter, [Fe(TBDAP)(NO)(H2O)]2+ (1), which was synthesized and precisely characterized by various physicochemical methods, including X-ray crystallography. In the animal model, normal retinal blood vessels were confirmed to be dilated by
the photoresponsive iron–nitrosyl complex. Furthermore, occluded retinal blood vessels were effectively reperfused after the immediate delivery of nitric oxide using light in animal disease models. These studies suggest an unprecedentedly selective and controllable treatment option for acute vascular occlusive diseases, including cardiovascular and cerebrovascular diseases.
Issued Date
2023
Jisu Choe
Soo Jin Kim
Jun-Hyeong Kim
Mu-Hyun Baik
Junyeop Lee
Jaeheung Cho
Type
Article
Keyword
nitric oxidevasodilationmetal–nitrosyl complexphotoresponsive transferspatiotemporal controlmetal-to-ligand charge transferreperfusionSDG3: Good health and well-being
DOI
10.1016/j.chempr.2023.02.013
URI
https://oak.ulsan.ac.kr/handle/2021.oak/17549
Publisher
CHEM
Language
영어
ISSN
2451-9294
Citation Volume
9
Citation Start Page
1309
Citation End Page
1317
Appears in Collections:
Natural Science > Biological Sciences
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