동맥경화성 뇌혈관 질환의 발생양상 및 위험인자에 대한 고찰

Abstract

To study the etiologic characteristics of intracranial and extracranial artery occlusive disease in Korea, we analyzed risk factor data from 40 patients(32 men and 8 women with a mean age of 52.0 years) with symptomatic, angiographically proven atherosclerotic cerebrovascular disease from September 1991 to November 1992. Thirty-four patients had an intracrnial arterial lesion, while 9 had an extracranial one. Middle cerebral artery (MCA) occlusion or stenosis was found in 24 patients in which 18 had an isolated MCA lesion(17 had a MCA trunk lesion and 1 had a branch occlusion). Distal internal carotid artery(ICA), anterior cerebral artery, and vertebro-basilar artery occlusion or stenosis were seen in 6, 3, and 9 patients, respectively. Only three patients with intracranial artery disease had a significant stenosis or occlusion in the proximal ICA at the same time. Among the risk factors, hypertension(76%) and longstanding cigarette smoking(62%) were the most significant predictors of the presence of intracranial arterial occlusive disease, while hypertension and diabetes were the most significant in the extracranial disease. The predominance of intracranial artery occlusive diseases in Koreans may be related to the difference in risk factors compared with the Caucasians.

To study the etiologic characteristics of intracranial and extracranial artery occlusive disease in Korea, we analyzed risk factor data from 40 patients(32 men and 8 women with a mean age of 52.0 years) with symptomatic, angiographically proven atherosclerotic cerebrovascular disease from September 1991 to November 1992. Thirty-four patients had an intracrnial arterial lesion, while 9 had an extracranial one. Middle cerebral artery (MCA) occlusion or stenosis was found in 24 patients in which 18 had an isolated MCA lesion(17 had a MCA trunk lesion and 1 had a branch occlusion). Distal internal carotid artery(ICA), anterior cerebral artery, and vertebro-basilar artery occlusion or stenosis were seen in 6, 3, and 9 patients, respectively. Only three patients with intracranial artery disease had a significant stenosis or occlusion in the proximal ICA at the same time. Among the risk factors, hypertension(76%) and longstanding cigarette smoking(62%) were the most significant predictors of the presence of intracranial arterial occlusive disease, while hypertension and diabetes were the most significant in the extracranial disease. The predominance of intracranial artery occlusive diseases in Koreans may be related to the difference in risk factors compared with the Caucasians.