살리실산 나트륨이 Guinea Pig 내이 외림프의 Unknown Compoung에 미치는 영향

Abstract

There are some evidences that temporary hearing loss is induced by disturbance of cochlear microcirculation due to the inhibition of prostaglandin synthesis by salicylate, however, the mechanism of salicylate ototoxicity has been still under study.

We previously suggested that the increase of unknown compound concentration in perilymph of guinea pig might be important for the mechanism of salicylate ototoxicity. So we tried to compare the time course of unknown compound concentration to salicylate concentration in perilymph. Sodium salicylate(460mg/kg) was injected intraperitoneally to guinea pig. Unknown compound concentration in perilymph was measured before the injection and 1 hour, 3 hours, 5 hours, 7 hours and 24 hours after injection, using HPLC-ECD. The time course of unknown compound concentration reveals maximum level at 5 hours and nearly control level at 24 hours, and this is similar to the change of salicylate concentration in perilymph. These data might be another evidence to our understanding of unknown compound-related salicylate ototoxicity.

There are some evidences that temporary hearing loss is induced by disturbance of cochlear microcirculation due to the inhibition of prostaglandin synthesis by salicylate, however, the mechanism of salicylate ototoxicity has been still under study.

We previously suggested that the increase of unknown compound concentration in perilymph of guinea pig might be important for the mechanism of salicylate ototoxicity. So we tried to compare the time course of unknown compound concentration to salicylate concentration in perilymph. Sodium salicylate(460mg/kg) was injected intraperitoneally to guinea pig. Unknown compound concentration in perilymph was measured before the injection and 1 hour, 3 hours, 5 hours, 7 hours and 24 hours after injection, using HPLC-ECD. The time course of unknown compound concentration reveals maximum level at 5 hours and nearly control level at 24 hours, and this is similar to the change of salicylate concentration in perilymph. These data might be another evidence to our understanding of unknown compound-related salicylate ototoxicity.