위의 이형성증, 선종, 선암종에서의 Oncogene과 Suppressor gene의 발현에 관한 연구

Abstract

Immunohistochemical stainings were done to analyse the distribution of p53 and Rb proteins with various gastric epithelial lesions:normal, intestinal metaplasia, low grade and high grade gastric dysplasia, and gastric carcinoma. Normal and intestinal metaplastic epithelium revealed weak positivity for both p53 and Rb proteins. Low grade gastric dysplasia was also diffusely and mildly positive for two proteins. In contrast, in the area of high grade dysplasia, dysplastic cells were strongly positive in nuclei as well as in cytoplasm. Intranulclear strong immunostaining was persistant in gastric carcinomas regardless of histologic differences. It can be assumed that either p53 or Rb proteins may be involved in a spectrum of gastric epithelial changes directly or indirectly. Immunostaining for muted p53 proteins may be used to determine the degree of gastric dysplasia in association with light microscopic features.

Immunohistochemical stainings were done to analyse the distribution of p53 and Rb proteins with various gastric epithelial lesions:normal, intestinal metaplasia, low grade and high grade gastric dysplasia, and gastric carcinoma. Normal and intestinal metaplastic epithelium revealed weak positivity for both p53 and Rb proteins. Low grade gastric dysplasia was also diffusely and mildly positive for two proteins. In contrast, in the area of high grade dysplasia, dysplastic cells were strongly positive in nuclei as well as in cytoplasm. Intranulclear strong immunostaining was persistant in gastric carcinomas regardless of histologic differences. It can be assumed that either p53 or Rb proteins may be involved in a spectrum of gastric epithelial changes directly or indirectly. Immunostaining for muted p53 proteins may be used to determine the degree of gastric dysplasia in association with light microscopic features.