중이 진주종의 면역조직학적 고찰

Abstract

저자들은 진주종조직과 비진주종 조직에서 Langerhans 세포와 T림프구의 아형들의 분포를 면역조직학적 방법에 의해 관찰하고, 임상적으로 이루의 존재 유무와 연관시켜 고찰하여 다음과 같은 결과를 얻었다.

1) 비진주종성 조직 5례에서 Langerhans 세포들은 상피층에 나타나는 빈도가 적고 주로 상피층의 상기저부에 국한되어 있었으며, T림프구는 거의 관찰할 수 없었다.

2) 진주종조직 32례에서 Langerhans 세포들은 상피층에서는 항상 관찰되었으나, 상피하층에서는 25례에서만 관찰되었다.

3) 진주종조직에서 Langerhans 세포들은 상피층에서 상피하층으로 갈수록 분포밀도가 감소하였다.

4) 진주종 조직에서 T림프구의 아형들은 주로 상피하층에서 발견되었고, 조력 T림프구가 억제 T림프구보다 출현 빈도가 많았다.

5) 진주종 환자에서 임상적으로 이루가 있던 경우 Langerhans 세포의 분포밀도가 없던 경우에 비하여 높았으나, T림프구 아형들의 분포는 양군간에 차이가 없었다.

The etiopathogenesis of cholesteatoma is still unknown;however, it has been reported that Langerhans' cells and T-lymphocytes play an important role in the pathogenesis of aural cholesteatoma. The authors performed immunohistological study to identify the distribution of the Langerhans' cells and T-lymphocytes in 32 cases of cholesteatoma tissue and in 5 cases of chronic inflammation of aural skin, and to correlate with clinical symptom of otorrhea. CD1 monoclonal antibody was used to demonstrate Langerhans' cells, CD4 for helper T-lymphocytes, and CD8 for suppressor T-lymphocytes. Our results showed that Langerhans' cells and helper T-lymphocytes were found abundantly in the cholesteatoma tissue than in noncholesteatoma skin, and the proportion of Langerhans' cells in cholesteatoma tissue was higher in cases with otorrhea than in cases without otorrhea.

The etiopathogenesis of cholesteatoma is still unknown;however, it has been reported that Langerhans' cells and T-lymphocytes play an important role in the pathogenesis of aural cholesteatoma. The authors performed immunohistological study to identify the distribution of the Langerhans' cells and T-lymphocytes in 32 cases of cholesteatoma tissue and in 5 cases of chronic inflammation of aural skin, and to correlate with clinical symptom of otorrhea. CD1 monoclonal antibody was used to demonstrate Langerhans' cells, CD4 for helper T-lymphocytes, and CD8 for suppressor T-lymphocytes. Our results showed that Langerhans' cells and helper T-lymphocytes were found abundantly in the cholesteatoma tissue than in noncholesteatoma skin, and the proportion of Langerhans' cells in cholesteatoma tissue was higher in cases with otorrhea than in cases without otorrhea.