KLI

A prospective, open-label, randomized, non-inferiority pilot study to compare the dose (6.0mg/kg vs 4.5mg/kg) of antithymocyte globulin as an induction therapy in living donor kidney transplantation

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Abstract
The optimal dose of rabbit antithymocyte globulin as an induction regimen in Asian living donor kidney transplant recipients has rarely been investigated. Patients were randomly assigned to receive either 4.5 mg/kg (19 patients) or 6.0 mg/kg (17 patients) antithymocyte globulin. All patients had corticosteroid withdrawal within 7 days. The primary end point was a composite of the biopsy-proven acute rejection, development of de novo donor-specific antibody, or graft failure. At 24 months post-transplant, the composite end point rate was 42.1% in the 4.5 mg/kg group and 24.4% in the 6.0 mg/kg group. There was neither graft failure nor mortality during the follow-up period (22 to 40 months). We decided to stop the study earlier than planned because we were concerned about the higher composite end point rate in the 4.5 mg/kg group. Antithymocyte globulin induction at 4.5 mg/kg and early corticosteroid withdrawal increased the rate of de novo donor-specific antibody and biopsy-proven acute rejection.
Author(s)
고영민
Issued Date
2020
Awarded Date
2020-02
Type
Dissertation
Keyword
kidney transplantationantithymocyte globulininductiondosebiopsy-proven acute rejectiondonor-specific antibodygraft failure
URI
https://oak.ulsan.ac.kr/handle/2021.oak/6085
http://ulsan.dcollection.net/common/orgView/200000291981
Alternative Author(s)
Youngmin Ko
Affiliation
울산대학교
Department
일반대학원 의학과
Advisor
신성
Degree
Master
Publisher
울산대학교 일반대학원 의학과
Language
kor
Rights
울산대학교 논문은 저작권에 의해 보호받습니다.
Appears in Collections:
Medicine > 1. Theses (Master)
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