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Clinical usefulness of the diffusing capacity of the lung for carbon monoxide (DLco) in the identification of humidifier disinfectant-associated lung injury in children

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Abstract
Background: Humidifier disinfectant-associated lung injury (HDLI) is classified as an interstitial lung disease due to pulmonary fibrosis, which may be characterized by decreased DLco levels. Then, DLco can be a possible clinical marker of HDLI. However, there is no published information on DLco levels in HDLI children compared with controls. The purpose of this study was to establish a reference equation for DLco in healthy Korean children and to evaluate the levels of DLco in a national cohort of HDLI survivors and to compare those data to controls
Methods: DLco were performed in a nationwide cohort of HDLI survivors aged from 5 to 12 years. To investigate the reference value of DLco in controls, we recruited age- and sex-matched outpatients who had no exposure history of HD and underlying respiratory disease.
Results: The study population consisted of 67 HDLI survivors and 216 controls, respectively. Height is the most significant factor to influence the log-transformed DLco (LnDLco) in both sexes (boys, R2=0.724; girls, R2=0.734, respectively). Multiple regression equations were obtained for LnDLco using variables including age, height, and weight in both sexes (boy, R2=0.736; girl, R2=0.755, respectively). To compare HDLI survivors with controls, HDLI children have lower DLco than control groups. In particular, the mean difference is significantly higher in boys taller than 130cm (130–139cm, 12.6 vs. 9.5, P=0.055; 140–149cm, 16.4 vs. 12.8, P<0.001; 150cm≤, 20.3 vs. 16.2, P=0.050. respectively).
Conclusion: The DLco value increases with increased height, but the rate of increase in HDLI children is less than that of the control groups. DLco may be considered a useful pulmonary function test for HDLI survivor in children for the diagnosis and follow-up of HDLI.
Author(s)
조현주
Issued Date
2017
Awarded Date
2018-02
Type
Dissertation
Keyword
Diffusing capacityhumidifier disinfectantlung injurychildren
URI
https://oak.ulsan.ac.kr/handle/2021.oak/6148
http://ulsan.dcollection.net/common/orgView/200000010171
Alternative Author(s)
Hyun-Ju Cho
Affiliation
울산대학교
Department
일반대학원 의학과
Advisor
홍수종
Degree
Master
Publisher
울산대학교 일반대학원 의학과
Language
eng
Rights
울산대학교 논문은 저작권에 의해 보호받습니다.
Appears in Collections:
Medicine > 1. Theses (Master)
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