The effects of inflammation on bone and fat metabolism

Abstract

Bone loss is commonly considered the common process regulated by the inflammatory osteoclast cells commonly called as osteoclastogenesis. Studies have shown various roles played by specific microRNAs (miRs) in regulating this process. Specifically among them is miR-29b which has shown to be induced by inflammation stimulated by lipopolysaccharide (LPS) in both invitro and invivo systems also helps in increasing the survival rate of osteoclasts. miR-29b when expressed high the survival rate of osteoclasts were increased showing an anti-apoptotic pathway where as blockage of endogenous miR-29b declined the survival rate and also showed high apoptotic signals. BCL-2-modifying factor (Bmf) which itself is a pro-apoptocic factor was found to be the direct for miR-29b .thus by decreasing the expression of BMF , miR-29b acts as an effective modulator in increasing the survival rate of osteoclasts.