KLI

간세포암 절제에서 ADV score가 가지는 예후 평가의 효용성 입증

Metadata Downloads
Abstract
Background: We aimed to validate the prognostic power of the ADV score (alpha-fetoprotein [AFP]-des-γ-carboxyprothrombin [DCP]-tumor volume [TV] score, calculated as AFP [ng/mL]DCP [mAU/mL]TV [mL] and expressed in log10) for predicting patient survival after hepatocellular carcinoma (HCC) resection.
Methods: This study included 1390 patients with HCC registered in the Korea Liver Cancer Registry. Patients underwent hepatic resection between 2008 and 2012 and were followed up until December 2016. They were divided into 4 groups according to the number of tumors and preoperative treatment.
Results: There was no significant correlation among AFP, DCP, and TV values (r2≤0.04, p<0.001). In group 1 with single naïve tumor (n=1154), patient stratification with ADV 1log-interval and cutoffs of 5log, 7log, and 10log showed great prognostic contrast (p<0.001). In group 2 with multiple naïve tumors (n=170), patient stratification with ADV 1log-interval and above-mentioned 3 cutoffs also showed great prognostic contrast (p<0.001). In group 3 (n=50) and group 4 (n=16) with pretreated tumors, patient stratification with ADV 1log-interval and above-mentioned 3 cutoffs showed a noticeable prognostic contrast (p≤0.031). The ADV score based on preoperative findings also showed great prognostic contrast in 1106 patients preoperatively diagnosed as having single naïve tumor (p<0.001). Confining patients to tumor-node-metastasis stage I and II (n=1072) as well as Barcelona Clinic Liver Cancer stage 0 and A (n=862), ADV cutoffs showed further prognostic stratification.
Conclusions: This validation study strongly suggests that the ADV score is an integrated surrogate marker for postresection prognosis in HCC. The ADV score is primarily applicable to patients with single naïve HCC and can be expanded to those with multiple or pretreated HCCs.
Author(s)
최진욱
Issued Date
2020
Awarded Date
2020-02
Type
Dissertation
URI
https://oak.ulsan.ac.kr/handle/2021.oak/6453
http://ulsan.dcollection.net/common/orgView/200000289650
Affiliation
울산대학교
Department
일반대학원 의학과
Advisor
황신
Degree
Master
Publisher
울산대학교 일반대학원 의학과
Language
eng
Rights
울산대학교 논문은 저작권에 의해 보호받습니다.
Appears in Collections:
Medicine > 1. Theses (Master)
Authorize & License
  • Authorize공개
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.