KLI

근치적 방사선 치료 후 재발한 상피성장인자 수용체 돌연변이 비소세포폐암 환자에서 상피성장인자 수용체 티로신 키나아제 억제제의 효과

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Abstract
Background For patients with recurrent EGFR mutant non-small cell lung cancer (NSCLC), EGFR tyrosine kinase inhibitor (TKI) is the standard therapy. In this study, we evaluated efficacy of EGFR TKI in EGFR mutant NSCLC patients who recurred after definitive radiotherapy (RT) or concurrent chemo-radiation therapy (CCRT) by comparing with those who recurred after surgical resection.
Methods Patients with diagnosis of EGFR mutant NSCLC who received EGFR TKI after recurrence to definitive treatment (RT vs. surgery) at Asan Medical Center, Seoul, Korea were included. Survival curves between two groups were estimated by Kaplan-Meier method and compared using log-rank test. Overall survival (OS) was defined as from the initiation of EGFR TKI to any cause of death, and progression-free survival (PFS) was defined as from the initiation of EGFR TKI to objective disease progression or any cause of death.
Results Total 56 patients were included in analysis (21 in RT group vs. 35 in surgery group). Clinical characteristics were similar between two groups, including disease status at recurrence (Logo-regional vs. distant metastasis). Median OS was significantly shorter in the RT group compared to the surgery group (15.6 vs. 47.2 months, P=0.001). This remained significant in multivariate analysis including potential prognostic factors (HR 3.03, 95% CI 1.45-6.25, P=0.003). Median PFS was also significantly shorter in the RT group compared to the surgery group (8.5 vs. 14.5 months, P=0.045), but adjusted HR was not statistically significant (P=0.138).
Conclusion In patients with EGFR mutant NSCLC who received EGFR TKI after recurrent to definitive RT or CCRT, OS and PFS was significantly shorter compared to those who received EGFR TKI after recurrence to surgery.
Author(s)
형재원
Issued Date
2019
Awarded Date
2020-02
Type
Dissertation
Keyword
non-small cell lung cancerEGFREGFR TKIdefinitive radiotherapyNSCLC
URI
https://oak.ulsan.ac.kr/handle/2021.oak/6552
http://ulsan.dcollection.net/common/orgView/200000284831
Alternative Author(s)
Jaewon Hyung
Affiliation
울산대학교
Department
일반대학원 의학과의학전공
Advisor
이재철
Degree
Master
Publisher
울산대학교 일반대학원 의학과의학전공
Language
eng
Rights
울산대학교 논문은 저작권에 의해 보호받습니다.
Appears in Collections:
Medicine > 1. Theses (Master)
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