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두경부암의 방사선 저항성 획득에 있어 EphA3의 역할 규명

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Abstract
Radiotherapy is a well-established therapeutic modality used in the treatment of many cancers. However, radioresistance remains a serious obstacle to successful treatment. Radioresistance can cause local recurrence and distant metastases in some patients after radiation treatment. Thus, many studies have attempted to identify effective radiosensitizers.
Eph receptor functions contribute to tumor development, modulating cell-cell adhesion, invasion, neo-angiogenesis, tumor growth and metastasis. However, the role of EphA3 in radioresistance remains unclear.
In the current study, we established a stable radioresistant head and neck cancer cell line (AMC HN3R cell line) and found that EphA3 was expressed predominantly in the radioresistant head and neck cancer cell line through DNA microarray, real time PCR and Western blotting. Additionally, we found that EphA3 was overexpressed in recurrent laryngeal cancer specimens after radiation therapy. EphA3 mediated the tumor invasiveness and migration in radioresistant head and neck cancer cell lines and epithelial mesenchymal transition- related protein expression. Inhibition of EphA3 enhanced radiosensitivity in the AMC HN 3R cell line in vitro and in vivo study. In conclusion, our results suggest that EphA3 is overexpressed in radioresistant head and neck cancer and plays a crucial role in the development of radioresistance in head and neck cancers by regulating the epithelial mesenchymal transition pathway.
Author(s)
김송희
Issued Date
2018
Awarded Date
2019-02
Type
Dissertation
Keyword
두경부암EphA3방사선 저항방사선 감수성epthelial-to-mesenchymal transition (EMT)
URI
http://oak.ulsan.ac.kr/handle/2021.oak/6690
http://ulsan.dcollection.net/common/orgView/200000171277
Alternative Author(s)
KIM Song Hee
Affiliation
울산대학교
Department
일반대학원 의학과의과학전공
Advisor
한명월
Degree
Doctor
Publisher
울산대학교 일반대학원 의학과의과학전공
Language
eng
Rights
울산대학교 논문은 저작권에 의해 보호받습니다.
Appears in Collections:
Medical Science > 2. Theses (Ph.D)
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