베체트 병 환자에서 심혈관계 질환의 위험성: 전국민 기반 표본 코호트의 후향적 분석

Abstract

Few studies have investigated the correlation between Behçet disease (BD) and cardiovascular diseases (CVD). We investigated the risk of CVD in patients with BD. Between 2003 and 2015, we performed a retrospective cohort study involving patients with BD selected from the National Health Insurance Service-National Sample Cohort database and age- and sex-matched controls. Logistic regression analysis was performed to examine the association between BD and comorbidities. Cox proportional hazards regression analysis was performed to compare the hazard ratio (HR) of diseases that showed significance using logistic regression analysis. Among the 998 patients with BD and the 4,990 controls studied, patients with BD showed a significantly higher risk for angina pectoris (adjusted HR 1.522, 95% confidence interval [CI] 1.020–2.273) and peripheral arterial disease (adjusted HR 2.939, 95% CI 1.296–6.664) than controls. The cumulative incidence rates of these diseases in patients with BD were also significantly higher than those in controls (log-rank p=0.005 and 0.007 for angina pectoris and peripheral arterial disease, respectively). This study demonstrated that patients with BD showed an independent risk for angina pectoris and peripheral arterial disease.