물에 녹는 고분자를 사용하여 기하이성질체의 차별화 발견

Abstract

Water-soluble copolymers were prepared by reversible addition-fragmentation chain transfer polymerization (RAFT), which is used for successful discrimination between maleic acid and structurally similar fumaric acid. After polymerization, we can get a series of polymeric probes (P1, P2, and P3) that various pendent –R groups (i.e., aldehydes, thiazolidines, and nitriles) containing azo chromophore. In case of P1 (aldehyde group), maleic acid and fumaric acid containing other carboxyl groups afforded the selective colorimetric detection. In case of P2 (thiazolidine ring), maleic acid and fumaric acid did not afforded the selective detection but discriminate from other carboxylic acids. Finally, P3 did not discriminate all carboxylic acids including maleic acid and fumaric acid. These results were influenced by the magnitude of the acid dissociation constant of the polymer probe. In this regard, these pKa could be important parameters to understand the mechanism of selective analysis sensing.