KLI

성인 중환자에서 마약성 진통제 중단 증후군에 대한 후향적 코호트 연구

Metadata Downloads
Abstract
Background: Opioid withdrawal syndrome (OWS) may occur following the reduction or discontinuation of opioid analgesics. In critically ill pediatric patients, OWS is a common and clinically significant condition. As OSW in adult patients has not been assessed in detail, this study aimed to investigate the incidence, risk factors, and clinical features of OWS in patients treated in an adult intensive care unit (ICU).
Methods: This study was a retrospective evaluation of data from patients treated in the medical ICU for ≥ 3 days and who received only one type of opioid analgesic. OWS was assessed over a 24 hour period from discontinuation or reduction (by > 50%) of continuous opioid infusion. OWS was defined as the presence of ≥ 3 central nervous system or autonomic nervous system symptoms.
Results: In 126 patients treated with remifentanil (n = 58), fentanyl (n = 47), or morphine (n = 21), OWS was seen in 31.0%, 36.2%, and 9.5% of patients, respectively (p = 0.078). The most common symptom was a change in respiratory rate (remifentanil, 94.4%; fentanyl, 76.5%; morphine, 100%). Multivariate Cox-proportional hazards model showed that OWS was associated with morphine treatment (hazard ratio: 0.17, 95% CI: 0.037–0.743) and duration of opioid infusion (hazard ratio: 0.566, 95% CI: 0.451–0.712).
Conclusions: No statistically significant difference in the incidence of OWS was observed among patients treated with different types of opioid analgesics, although a lower frequency was seen in patients receiving morphine. Prospective studies are required to confirm these preliminary results.
Author(s)
현동곤
Issued Date
2018
Awarded Date
2019-02
Type
Dissertation
Keyword
Analgesicsintensive care unitsubstance withdrawal syndromeincidence
URI
https://oak.ulsan.ac.kr/handle/2021.oak/6824
http://ulsan.dcollection.net/common/orgView/200000176990
Alternative Author(s)
Dong-gon Hyun
Affiliation
울산대학교
Department
일반대학원 의학과
Advisor
임채만
Degree
Master
Publisher
울산대학교 일반대학원 의학과
Language
eng
Rights
울산대학교 논문은 저작권에 의해 보호받습니다.
Appears in Collections:
Medicine > 1. Theses (Master)
Authorize & License
  • Authorize공개
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.