KLI

성인 털모양별아교세포종의 임상양상 및 예후인자에 대한 후향적 분석 연구

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Abstract
Abstract
Background
Pilocytic astrocytomas (PAs) frequently affect the pediatric population. On the contrary, only rare case series in adults were reported. Some reported adult PA represented more aggressive behavior than pediatric patients but it is a relatively unknown entity about their prognosis and management. The goal of this study is to evaluate prognostic factors and treatment outcomes in adult PA patients to assess overall prognosis after surgery.

Methods
We reviewed 71 adult patients diagnosed of PA in single institution between 1999 and 2017. We investigated OS (overall survival) and PFS (progression-free survival) of our patients along with prognostic factors. PFS and OS were calculated using the Kaplan-Meier method. Prognostic factors were analyzed using Cox-Proportional Hazard model.

Results
A total of 71 adult patients were diagnosed with PA at our institution between 1999 and 2017 (40 men and 31 women). During the median follow-up of 75.6 months, progression or recurrence of tumor occurred in 19 patients (26.8%). The extent of resection was strongly correlated to both PFS and OS (Kaplan Meier estimates, log-rank test, p<0.001) The overall survival rates at 5 year with APAs who achieved CR, PR and biopsy were 97%, 94% and 56%, respectively. And progression free survival rates at 5 year in CR, PR and biopsy patients were 91%, 63% and 32%, respectively.

Conclusion
Adult PAs have more aggressive clinical behavior than pediatric PAs. Our study showed extent of resection (EOR); STR and biopsy, age of 40 or over and deep location were associated with poor prognostic factors for OS and PFS.
Author(s)
서정한
Issued Date
2018
Awarded Date
2019-02
Type
Dissertation
Keyword
Pilocytic astrocytoma
URI
https://oak.ulsan.ac.kr/handle/2021.oak/6825
http://ulsan.dcollection.net/common/orgView/200000171691
Alternative Author(s)
Junghan Seo
Affiliation
울산대학교
Department
일반대학원 의학과
Advisor
김정훈
Degree
Master
Publisher
울산대학교 일반대학원 의학과
Language
eng
Rights
울산대학교 논문은 저작권에 의해 보호받습니다.
Appears in Collections:
Medicine > 1. Theses (Master)
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