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수술 가능한 췌장암 환자에서의 PET/CT 의 유용성: 림프절 전이 진단 및 생존율 예측

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Abstract
Purpose: To evaluate the diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) for lymph node (LN) metastasis and the prognostic significance of FDG PET/CT LN parameters in patients with resectable pancreatic cancer.

Patients and Methods: Patients with resectable pancreatic cancer who underwent staging FDG PET/CT between May 2007 and September 2016 were retrospectively enrolled and analyzed through medical record and image reevaluation. The diagnostic accuracy of FDG PET/CT in predicting LN metastasis was evaluated and compared with that of enhanced CT. Prognostic variables, including LN parameters assessed by FDG PET/CT (standardized uptake value [SUV]LN and LN/tumor SUV ratio), that affect disease-free survival (DFS) and overall survival (OS) were evaluated by regression analysis.

Results: When predicting LN metastasis, FDG PET/CT showed greater sensitivity, positive predictive value, negative predictive value, and accuracy than enhanced CT. Among prognostic factors affecting DFS, PET-positive LN (p = 0.008) and LN/tumor SUV ratio (p = 0.003) were found to be significant by regression analysis. Among variables affecting OS, lympho-vascular invasion (p = 0.018) and LN/tumor SUV ratio (p = 0.046) were found to be significant.

Conclusion: FDG PET/CT showed higher diagnostic accuracy in predicting LN metastasis than enhanced CT in patients with resectable pancreatic cancer. Only LN/tumor SUV ratio of FDG PET/CT was an independent prognostic variable in both DFS and OS.
Author(s)
김형래
Issued Date
2017
Awarded Date
2018-02
Type
Dissertation
Keyword
pancreatic cancerFDG PET/CTLN metastasislymph node to tumor SUV ratiodisease free survivaloverall survival
URI
https://oak.ulsan.ac.kr/handle/2021.oak/6849
http://ulsan.dcollection.net/common/orgView/200000002794
Alternative Author(s)
Hyung Rae Kim
Affiliation
울산대학교
Department
일반대학원 의학과의학전공
Advisor
조재철
Degree
Master
Publisher
울산대학교 일반대학원 의학과의학전공
Language
eng
Rights
울산대학교 논문은 저작권에 의해 보호받습니다.
Appears in Collections:
Medicine > 1. Theses (Master)
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