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Effects of different definitions of low muscle mass on its association with metabolic syndrome in older adults: a Korean nationwide study

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Abstract
Aim: We aimed to investigate the association between low muscle mass (LMM) and
metabolic syndrome (MetS) according to the definition of LMM.

Methods: This study used data from the Korean National Health and Nutrition Examination
Survey conducted from 2008 to 2011. We used appendicular skeletal muscle adjusted for
height (ASM/Ht2) and weight (ASM/Wt) as definitions of LMM. Class I and Class II LMM
were defined as ASM/Ht2 or ASM/Wt from 1 to 2 standard deviations (SDs) or 2 SDs below
the mean for young adults, respectively.

Results: A total of 6370 participants were included in analysis: 58.5% were women. The mean
age of participants in this study sample was 72.3 4.8 years. In the fully adjusted model, ASM/Ht2
was inversely related to MetS prevalence (adjusted odds ratio [aOR] 0.770, 95% confidence interval
[CI] 0.600?0.988 for class I, aOR 0.473, 95% CI, 0.327?0.684 for class II). In contrast, MetS prevalence
increased in class I (aOR 1.902, 95% CI 1.510?2.396) and class II LMM (aOR 2.831, 95% CI
2.194?3.655) using ASM/Wt. ASM/Ht2 was proportional to the waist circumference and the number
of metabolic features, whereas ASM/Wt was inversely proportional in both sexes. Stratified
analysis showed that the association was robust regardless of the cardiovascular risk factors.

Conclusion: In Korean older adults, ASM/Wt is positively associated with MetS prevalence,
whereas ASM/Ht2 is inversely associated, regardless of the cardiovascular risk factors. Waist
circumference and the number of metabolic features were directly proportional to ASM/Ht2,
but inversely proportional to ASM/Wt.
Author(s)
전예림손기영
Issued Date
2021
Type
Article
Keyword
AgedAnalysislow muscle massmetabolic syndromeMusclesOlder peoplesarcopeniawaist circumference
DOI
10.1111/ggi.14277
URI
https://oak.ulsan.ac.kr/handle/2021.oak/6966
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2574736090&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Effects%20of%20different%20definitions%20of%20low%20muscle%20mass%20on%20its%20association%20with%20metabolic%20syndrome%20in%20older%20adults:%20a%20Korean%20nationwide%20study&offset=0&pcAvailability=true
Publisher
Geriatrics and Gerontology International
Location
일본
Language
한국어
ISSN
1447-0594
Citation Volume
21
Citation Number
11
Citation Start Page
1003
Citation End Page
1009
Appears in Collections:
Medicine > Medicine
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