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Metabolic health is a determining factor for incident colorectal cancer in the obese population: A nationwide population-based cohort study

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Abstract
Background: The association of the risk of colorectal cancer (CRC) with obesity or obesity-induced metabolic disturbances remains controversial. We assessed the association of metabolic health status with incident CRC among subjects with obesity. Methods: This study included 319,397 subjects from the Korean National Health Insurance Service-National Health Screening Cohort. Transitions in metabolic health status and obesity were examined during 2009?2010 and 2011?2012. We categorized subjects with obesity into four separate groups according to their dynamic metabolic health status: metabolically healthy obesity (MHO), MHO to metabolically unhealthy obesity (MUO), MUO to MHO, and stable MUO. Subjects were followed up from 2009 to 2015 for incident CRC. Results: The stable MHO group showed no increased risk of incident CRC (hazard ratio [HR], 0.97; 95% confidence interval [CI], 0.83?1.14). However, the MHO to MUO group had a higher risk of incident CRC than the stable metabolically healthy nonobese (MHNO) group (HR, 1.34; 95% CI, 1.15?1.57). Among patients with MUO at baseline, those in the subgroup who transitioned to MHO group were not at increased risk of CRC (HR, 1.06; 95% CI, 0.91?1.25), whereas those who remained in the stable MUO group had a higher risk of incident CRC than those in the stable MHNO group (HR, 1.29; 95% CI, 1.19?1.41). Conclusions: The transition of metabolic health was a determining factor for CRC among subjects with obesity. Hence, maintenance or recovery of metabolic health should be addressed to prevent CRC in individuals with obesity.
Author(s)
김예지김휘승박중열이우제이지우정창희조윤경
Issued Date
2021
Type
Article
Keyword
AnalysisAntihypertensivesBody mass indexCancerClinical Cancer ResearchCodesColorectal cancerColorectal carcinomaDiabetesDiseaseHealth insuranceHypertensionInflammatory bowel diseaseMedical screeningmetabolic syndromeMetabolismMortalityNational health insurancenationwide cohort studyObesityExperimental Original Researchphenotypic transitionPolypsPopulationPopulation studiesResearchRisk factors
DOI
10.1002/cam4.3607
URI
https://oak.ulsan.ac.kr/handle/2021.oak/6981
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7826459&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Metabolic%20health%20is%20a%20determining%20factor%20for%20incident%20colorectal%20cancer%20in%20the%20obese%20population:%20A%20nationwide%20population-based%20cohort%20study&offset=0&pcAvailability=true
Publisher
Cancer Medicine
Location
미국
Language
영어
ISSN
2045-7634
Citation Volume
10
Citation Number
1
Citation Start Page
220
Citation End Page
229
Appears in Collections:
Medicine > Medicine
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