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Long-term Outcomes and Factors Affecting the Survival of Patients with Mucosal Esophageal Squamous Cell Carcinoma

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Alternative Title
Long-term Outcomes and Factors Affecting the Survival of Patients with Mucosal Esophageal Squamous Cell Carcinoma
Abstract
Background/Aims: Data regarding the prognosis of early esophageal cancer are lacking. This
study investigated the long-term outcomes and factors affecting the survival of patients with mucosal
esophageal squamous cell carcinoma (T1aESCC).
Methods: We analyzed the clinical and tumor-specific parameters of 263 patients who received
surgical resection (SR; n=63) or endoscopic resection (ER; n=200) for T1aESCC. Underlying
comorbidities were scored using the Charlson Comorbidity Index (CCI). Overall survival (OS)
was the primary outcome, and multivariate regression analysis was performed to predict factors
for OS.
Results: Of the study patients (age, 64.5±8.0 years), the CCI was 1.0±1.4 in the ER group and
0.6±0.9 in the SR group (p=0.107). The 5-year OS rate during follow-up (54.4±20.4 months)
was 85.7% (ER group, 86.8%; SR group, 82.4%; p=0.631). The cumulative 5-year incidence of
esophageal cancer recurrence was 10.5% in the ER group (vs 0% in the SR group). The overall
mortality rate was 12.9% (12.0% in the ER group and 15.9% in the SR group; p=0.399). The
most common cause of mortality was second primary cancers in the ER group (75%) and organ
dysfunction or postoperative complications in the SR group (70%). According to multivariate
analysis, only CCI was significantly associated with OS (p<0.001). The 5-year OS rate in patients
with a CCI >2 and in those with a CCI ≤2 was 60.2% and 88.2%, respectively (p<0.001). The
treatment method (ER vs SR) was not a significant affecting factor (p=0.238).
Conclusions: The long-term prognosis of patients with T1aESCC was significantly associated
with underlying comorbidities.
Author(s)
김가희나희경안지용이정훈정기욱김도훈김형렬최기돈송호준김용희이진혁정훈용박승일
Issued Date
2021
Type
Article
Keyword
EsophagusSquamous cell carcinomaEndoscopic mucosal resectionEsophagectomy
DOI
10.5009/gnl20254
URI
https://oak.ulsan.ac.kr/handle/2021.oak/6984
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9861798&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Long-term%20Outcomes%20and%20Factors%20Affecting%20the%20Survival%20of%20Patients%20with%20Mucosal%20Esophageal%20Squamous%20Cell%20Carcinoma&amp;offset=0&amp;pcAvailability=true
Publisher
Gut and Liver
Location
대한민국
Language
영어
ISSN
1976-2283
Citation Volume
15
Citation Number
5
Citation Start Page
705
Citation End Page
712
Appears in Collections:
Medicine > Medicine
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