KLI

Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise -Induced High-Turnover Metabolism

Metadata Downloads
Abstract
Low-grade mitochondrial stress can promote health and longevity, a phenomenon termed mitohormesis. Here, we demonstrate the opposing metabolic effects of low-level and high-level mitochondria! ribosomal (mitoribosomal) stress in hypothalamic proopiomelanocortin (POMC) neurons. POMC neuron -specific severe mitoribosomal stress due to Crifl homodeficiency causes obesity in mice. By contrast, mild mitoribosomal stress caused by Crifl heterodeficiency in POMC neurons leads to high -turnover metabolism and resistance to obesity. These metabolic benefits are mediated by enhanced thermogenesis and mitochondrial unfolded protein responses (UPRmt) in distal adipose tissues. In POMC neurons, partial Crifl deficiency increases the expression of 1i -endorphin ((i-END) and mitochondria! DNA -encoded peptide MOTS -c. Central administration of MOTS -c or ii -END recapitulates the adipose phenotype of Crifl heterodeficient mice, suggesting these factors as potential mediators. Consistently, regular running exercise at moderate intensity stimulates hypothalamic MOTS-cM-END expression and induces adipose tissue UPRmt and thermogenesis. Our findings indicate that POMC neuronal mitohormesis may underlie exercise -induced high -turnover metabolism.
Author(s)
김경곤김민선Chae Beom ParkChan Hee LeeChanghan LeeCheol Soo ChoiGil Myoung KangHong DuguHyo Sun LimJae Geun KimJae Woo ParkJi Ye KimJong Han ChoiMin Jeong ChoiMinho ShongSaet-Byel JungSe Eun ParkSe Hee MinSeongjun KimWon Hee JangYoung Min ChoYoung-Bum Kim
Issued Date
2021
Type
Article
Keyword
mitochondriastressribosomehypothalamusmetabolismthermogenesisexerciseproopiomelanocortinadiposeobesity
DOI
10.1016/j.cmet.2021.01.003
URI
https://oak.ulsan.ac.kr/handle/2021.oak/6986
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2486463352&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Mitohormesis%20in%20Hypothalamic%20POMC%20Neurons%20Mediates%20Regular%20Exercise%20-Induced%20High-Turnover%20Metabolism&offset=0&pcAvailability=true
Publisher
CELL METABOLISM
Location
미국
Language
영어
ISSN
1550-4131
Citation Volume
33
Citation Number
2
Citation Start Page
334
Citation End Page
334
Appears in Collections:
Medicine > Medicine
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.