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Active Treatment Improves Overall Survival in Extremely Older Non-Small Cell Lung Cancer Patients: A Multicenter Retrospective Cohort Study

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Abstract
Purpose As the aging of society progresses, the proportion of extremely older lung cancer patients has also increased; However, studies of these patients with non-small cell lung cancer are limited. Therefore, we investigated the initial treatment modalities and survival outcomes for patients aged 80 years or over.

Materials and Methods We included a multicenter retrospective cohort from the Korean Association for Lung Cancer Registry, which surveys 10% of the newly diagnosed lung cancer patients across 52 hospitals in Korea. We analyzed and compared the 2014-2016 data of the non-small cell lung cancer patients aged >= 80 years and those aged < 80 years.

Results Of the 6,576 patients reviewed, 780 patients were aged >= 80 years, and 5,796 patients were aged < 80 years. In the patients aged >= 80 years, surgery and radiation therapy resulted in longer patient survival among those with a resectable tumor (stage I-II) than the best supportive care (median survival, not reached [surgery] vs. 32.2 months [radiation therapy] vs. 11.43 months [best supportive care]). The duration of survival in patients with advanced-stage (IV) lung cancers was higher after chemotherapy than after the best supportive care (median survival, 8.63 months vs. 2.5 months). Patients with stage IV adenocarcinoma who received targeted therapy had better survival than those who did not (median survival, 9.0 months vs. 4.3 months).

Conclusion Even in extremely older patients, active treatments, such as surgery, radiation therapy, and chemotherapy, can result in better survival outcomes than the best supportive care.
Author(s)
이재철최창민Su Yeon LeeWonjun JiYoon-Ki Hong
Issued Date
2021
Type
Article
Keyword
CarcinomaNon–small cell lung carcinomaAged 80 years or aboveSurvival analysis
DOI
10.4143/crt.2020.894
URI
https://oak.ulsan.ac.kr/handle/2021.oak/6987
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9672828&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Active%20Treatment%20Improves%20Overall%20Survival%20in%20Extremely%20Older%20Non-Small%20Cell%20Lung%20Cancer%20Patients:%20A%20Multicenter%20Retrospective%20Cohort%20Study&amp;offset=0&amp;pcAvailability=true
Publisher
CANCER RESEARCH AND TREATMENT
Location
대한민국
Language
영어
ISSN
1598-2998
Citation Volume
53
Citation Number
1
Citation Start Page
104
Citation End Page
111
Appears in Collections:
Medicine > Medicine
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