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The effectiveness of vitamin C for patients with severe viral pneumonia in respiratory failure

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Abstract
Background: Vitamin C is a well-known antioxidant and essential cofactor for numerous biological reactions. Several studies reported that vitamin C can improve the symptoms and prognosis of patients with sepsis and respiratory infection. We aimed to examine the effect of vitamin C when used in viral pneumonia patients with severe respiratory failure.

Methods: Total 201 patients with viral pneumonia were included, of them 35 patients used vitamin C. We performed a statistical analysis through a propensity score matching of the age and baseline characteristics of these patients.

Results: There were differences between the vitamin C group and non-vitamin C group in terms of age (60 +/- 15 vs. 66 +/- 14, P=0.03), extracorporeal membrane oxygenation (28.6% vs. 5.4%, P<0.001), and procalcitonin (3 +/- 8 vs. 9 +/- 23, P=0.02). The 28-day mortality was not different between the two groups (20.0% vs. 24.7%, P=0.33). In the propensity-matched group, the 28-day mortality was not significantly different between the two groups (20.0% vs. 37.1%, P=0.07). Moreover, no difference was observed in shock reversal within 14 days (45.7% vs. 25.7%, P=0.08) and recovery after acute kidney injury (52.9% vs. 66.7%, P=0.41) between the two groups. Vitamin C was not a prognostic factor for 28-day mortality (P=0.33).

Conclusions: In this study adjunctive intravenous vitamin C therapy alone was not associated with improvement of the 28-day mortality and prognosis in patients with severe viral pneumonia with respiratory failure.
Author(s)
고윤석이재승임채만허진원홍상범Song-I Lee
Issued Date
2021
Type
Article
Keyword
Acute respiratory distress syndrome (ARDS)ascorbic acidcritical careviral pneumonia
DOI
10.21037/jtd-20-1306
URI
https://oak.ulsan.ac.kr/handle/2021.oak/6993
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2501477099&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,The%20effectiveness%20of%20vitamin%20C%20for%20patients%20with%20severe%20viral%20pneumonia%20in%20respiratory%20failure&amp;offset=0&amp;pcAvailability=true
Publisher
JOURNAL OF THORACIC DISEASE
Location
홍콩
Language
영어
ISSN
2072-1439
Citation Volume
13
Citation Number
2
Citation Start Page
632
Citation End Page
641
Appears in Collections:
Medicine > Medicine
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