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The shape of the left lateral ridge as a predictor of long-term outcome of catheter ablation for atrial fibrillation based on clinical and experimental data

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Abstract
Background: The left lateral ridge (LLR) is an important structure for ablation of atrial fibrillation (AF). This study assessed how the LLR shape is associated with the long-term outcomes of AF ablation and investigated the relationship with radiofrequency (RF) lesion formation.

Methods and results: Clinical study - we assessed multi-detector computed tomography (MDCT) images in 247 patients who underwent AF ablation. Patients were classified into two groups according to the shape of the LLR: Narrow LLR group (n = 116; 47%) and Wide LLR group (n = 131; 53%). After a follow-up period 475 +/- 245 days, the AF-free rate was significantly higher in the wide LLR than Narrow LLR group (832% vs. 62.9%, p = 0.0004). A multivariate analysis showed that the shape of the LLR was an independent predictor of AF recurrence after ablation (hazard ratio 258; 95% confidential interval= 1.48-451, p = 0.001).

Experimental study - Two types of the ridge models were made with porcine atrial tissues: "Narrow ridge(4.2 +/- 0.9 mm)" and "Wide ridge(9.7 = 1.8 mm)" RF ablation was performed on each ridge model using a contact force (CF)-sensing catheter. The mean CF and the RF lesion volume of the narrow ridge were significantly less than those of the wide ridge model (5.42 +/- 3.13 g vs. 10.37 +/- 3.98 g, p = 0.001; 19.8 +/- 9.9 mm(3) vs. 44.2 +/- 13.6 mm(3), p <0.001, respectively).

Conclusions: AF recurrence after ablation was more frequent in patients with a narrow LLR. LLR shape as assessed using MDCT is associated with long-term outcomes after AF ablation. CF and lesion formation data using the porcine atrial tissue model support our clinical results. (C) 2020 Elsevier B.V. All rights reserved.
Author(s)
김선화김유리김유호남기병최기준
Issued Date
2021
Type
Article
Keyword
AblationAblation (Surgery)Atrial fibrillationLeft lateral ridgeOutcomes
DOI
10.1016/j.ijcard.2020.12.055
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7011
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2473740884&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,The%20shape%20of%20the%20left%20lateral%20ridge%20as%20a%20predictor%20of%20long-term%20outcome%20of%20catheter%20ablation%20for%20atrial%20fibrillation%20based%20on%20clinical%20and%20experimental%20data&amp;offset=0&amp;pcAvailability=true
Publisher
INTERNATIONAL JOURNAL OF CARDIOLOGY
Location
미국
Language
영어
ISSN
0167-5273
Citation Volume
329
Citation Number
1
Citation Start Page
91
Citation End Page
98
Appears in Collections:
Medicine > Medicine
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