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Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors

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Abstract
Background and aims: The atherogenic index of plasma (AIP) has been suggested as a marker of plasma athe-rogenicity. This study aimed to assess the association between AIP and the rapid progression of coronary atherosclerosis using serial coronary computed tomography angiography (CCTA).

Methods: A total of 1488 adults (60.9 +/- 9.2 years, 58.9% male) who underwent serial CCTA with a median inter-scan period of 3.4 years were included. AIP was defined as the base 10 logarithm of the ratio of the concen-trations of triglyceride to high-density lipoprotein cholesterol. Rapid plaque progression (RPP) was defined as the change of percentage atheroma volume (PAV) >1.0%/year. All participants were divided into three groups based on AIP tertiles.

Results: Baseline total PAV (median [interquartile range (IQR)]) (%) (group I [lowest]: 1.91 [0.00, 6.21] vs. group II: 2.82 [0.27, 8.83] vs. group III [highest]: 2.70 [0.41, 7.50]), the annual change of total PAV (median [IQR]) (%/year) (group I: 0.27 [0.00, 0.81] vs. group II: 0.37 [0.04, 1.11] vs. group III: 0.45 [0.06, 1.25]), and the incidence of RPP (group I: 19.7% vs. group II: 27.3% vs. group III: 31.4%) were significantly different among AIP tertiles (all p < 0.05). In multiple logistic regression analysis, the risk of RPP was increased in group III (odds ratio: 1.52, 95% confidence interval: 1.02-2.26; p = 0.042) compared to group I after adjusting for clinical factors and baseline total PAV.

Conclusions: Based on serial CCTA findings, AIP is an independent predictive marker for RPP beyond traditional risk factors.
Author(s)
김용진박형복성지민신상훈원기범이병권이상은장혁재전은주최정현허란Daniel S BermanDaniele AndreiniEdoardo ConteErica MaffeiFay Y. LinFilippo CademartiriGianluca PontoneHabib SamadyHugo MarquesIlan GottliebJagat NarulaJames K MinJeroen J BaxJonathon A LeipsicKavitha ChinnaiyanL
Issued Date
2021
Type
Article
Keyword
Atherogenic index of plasmaAtherosclerosisCoronary artery diseaseCoronary computed tomography angiographyDevelopment and progressionRisk factors
DOI
10.1016/j.atherosclerosis.2021.03.009
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7019
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2508888400&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Atherogenic%20index%20of%20plasma%20and%20the%20risk%20of%20rapid%20progression%20of%20coronary%20atherosclerosis%20beyond%20traditional%20risk%20factors&amp;offset=0&amp;pcAvailability=true
Publisher
ATHEROSCLEROSIS
Location
스웨덴
Language
영어
ISSN
0021-9150
Citation Volume
324
Citation Start Page
46
Citation End Page
51
Appears in Collections:
Medicine > Medicine
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