Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors
- Abstract
- Background and aims: The atherogenic index of plasma (AIP) has been suggested as a marker of plasma athe-rogenicity. This study aimed to assess the association between AIP and the rapid progression of coronary atherosclerosis using serial coronary computed tomography angiography (CCTA).
Methods: A total of 1488 adults (60.9 +/- 9.2 years, 58.9% male) who underwent serial CCTA with a median inter-scan period of 3.4 years were included. AIP was defined as the base 10 logarithm of the ratio of the concen-trations of triglyceride to high-density lipoprotein cholesterol. Rapid plaque progression (RPP) was defined as the change of percentage atheroma volume (PAV) >1.0%/year. All participants were divided into three groups based on AIP tertiles.
Results: Baseline total PAV (median [interquartile range (IQR)]) (%) (group I [lowest]: 1.91 [0.00, 6.21] vs. group II: 2.82 [0.27, 8.83] vs. group III [highest]: 2.70 [0.41, 7.50]), the annual change of total PAV (median [IQR]) (%/year) (group I: 0.27 [0.00, 0.81] vs. group II: 0.37 [0.04, 1.11] vs. group III: 0.45 [0.06, 1.25]), and the incidence of RPP (group I: 19.7% vs. group II: 27.3% vs. group III: 31.4%) were significantly different among AIP tertiles (all p < 0.05). In multiple logistic regression analysis, the risk of RPP was increased in group III (odds ratio: 1.52, 95% confidence interval: 1.02-2.26; p = 0.042) compared to group I after adjusting for clinical factors and baseline total PAV.
Conclusions: Based on serial CCTA findings, AIP is an independent predictive marker for RPP beyond traditional risk factors.
- Author(s)
- 김용진; 박형복; 성지민; 신상훈; 원기범; 이병권; 이상은; 장혁재; 전은주; 최정현; 허란; Daniel S Berman; Daniele Andreini; Edoardo Conte; Erica Maffei; Fay Y. Lin; Filippo Cademartiri; Gianluca Pontone; Habib Samady; Hugo Marques; Ilan Gottlieb; Jagat Narula; James K Min; Jeroen J Bax; Jonathon A Leipsic; Kavitha Chinnaiyan; L
- Issued Date
- 2021
- Type
- Article
- Keyword
- Atherogenic index of plasma; Atherosclerosis; Coronary artery disease; Coronary computed tomography angiography; Development and progression; Risk factors
- DOI
- 10.1016/j.atherosclerosis.2021.03.009
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/7019
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2508888400&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Atherogenic%20index%20of%20plasma%20and%20the%20risk%20of%20rapid%20progression%20of%20coronary%20atherosclerosis%20beyond%20traditional%20risk%20factors&offset=0&pcAvailability=true
- Publisher
- ATHEROSCLEROSIS
- Location
- 스웨덴
- Language
- 영어
- ISSN
- 0021-9150
- Citation Volume
- 324
- Citation Start Page
- 46
- Citation End Page
- 51
-
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- Medicine > Medicine
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