KLI

Prognostic Impact of Age at the Time o Diagnosis in Korean Patients with Diffuse Large B-cell Lymphoma in the Rituximab Era: A Single Institution Study

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Abstract
Purpose In contrast to the Western diffuse large B-cell lymphoma (DLBCL), prognostic impact of age in a Korean population with DLBCL has not been fully evaluated.

Materials and Methods Six hundred and eight DLBCL patients treated with rituximab-containing chemotherapeutic regimens from January 2002 to March 2012 in Asan Medical Center were enrolled. Survival models using the restricted cubic spine-transformed age variable were constructed to evaluate non-linear relationships between age and survival outcome. Finally, age was categorized according to the conventional international prognostic index (IPI), National Comprehensive Cancer Network (NCCN)-IPI, and Grupo Espanol de Linfomas/Trasplante Autologo de Medula Osea (GELTAMO)-IPI schemes and the prognostic implications were evaluated.

Results The relative hazard did not change significantly during the first to fifth decades, but began to increase exponentially in patients aged over 62 years. This pattern or relationship was also retained in a multivariate model fitted to the age-adjusted IPI and relative dose intensity. Multivariate survival analysis revealed that age > 75 years, but not age > 60 years, was associated independently with poor overall and progression-free survival when the relative dose intensity and age-adjusted IPI were taken into account.

Conclusion The outcome of DLBCL in Korean populations may deteriorate rapidly as age exceeds 62 years. Therefore, a consensus cutoff value for age in Korean DLBCL patients should be determined to better predict prognosis.
Author(s)
황희상김미정박찬식윤덕현서철원허주영고현정
Issued Date
2021
Type
Article
Keyword
Diffuse large B-cell lymphomaAgePrognosisStatistical model
DOI
10.4143/crt.2020.626
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7020
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9672861&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Prognostic%20Impact%20of%20Age%20at%20the%20Time%20o%20Diagnosis%20in%20Korean%20Patients%20with%20Diffuse%20Large%20B-cell%20Lymphoma%20in%20the%20Rituximab%20Era:%20A%20Single%20Institution%20Study&offset=0&pcAvailability=true
Publisher
CANCER RESEARCH AND TREATMENT
Location
대한민국
Language
한국어
ISSN
1598-2998
Citation Volume
53
Citation Number
1
Citation Start Page
270
Citation End Page
278
Appears in Collections:
Medicine > Medicine
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