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High level of medication adherence is required to lower mortality in patients with chronic hepatitis B taking entecavir: A nationwide cohort study

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Abstract
It is unclear whether suboptimal adherence contributes to adverse clinical outcomes in patients with chronic hepatitis B (CHB). Moreover, there is no consensus regarding the optimal level of drug adherence. This was a population-based historical cohort study including 51?975 adult CHB patients treated with entecavir (0.5?mg/d orally). Data were obtained from the Korean national health insurance service claims database, which covers >99% of the entire population, between 2007 and 2015. Medication adherence was categorized as high (proportion of days covered [PDC], ≥90%; n?=?32?089), intermediate (PDC, 80%-89%; n?=?10?197) and low (PDC, <80%; n?=?9689). During a median 4.5?years (maximal 9?years) of follow-up in 51?975 CHB patients treated with entecavir, multivariable analyses revealed that the risk of mortality/transplantation was significantly greater in the low-adherers (adjusted hazard ratio [HR], 1.38; P?<.001) and intermediate-adherers (adjusted HR, 1.44; P?<.001) than the high-adherers (P for trend?
Author(s)
이자연조송희김효정이한길고민정임영석
Issued Date
2021
Type
Article
Keyword
AnalysisEntecavirHepatitis Bhepatitis B virushepatocellular carcinomaMedical researchMedicineExperimentalmortalityNational health insurancePatient compliancePatient outcomesproportion of days covered
DOI
10.1111/jvh.13418
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7034
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2451132906&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,High%20level%20of%20medication%20adherence%20is%20required%20to%20lower%20mortality%20in%20patients%20with%20chronic%20hepatitis%20B%20taking%20entecavir:%20A%20nationwide%20cohort%20study&amp;offset=0&amp;pcAvailability=true
Publisher
JOURNAL OF VIRAL HEPATITIS
Location
미국
Language
영어
ISSN
1352-0504
Citation Volume
28
Citation Number
2
Citation Start Page
353
Citation End Page
363
Appears in Collections:
Medicine > Medicine
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