High level of medication adherence is required to lower mortality in patients with chronic hepatitis B taking entecavir: A nationwide cohort study
- Abstract
- It is unclear whether suboptimal adherence contributes to adverse clinical outcomes in patients with chronic hepatitis B (CHB). Moreover, there is no consensus regarding the optimal level of drug adherence. This was a population-based historical cohort study including 51?975 adult CHB patients treated with entecavir (0.5?mg/d orally). Data were obtained from the Korean national health insurance service claims database, which covers >99% of the entire population, between 2007 and 2015. Medication adherence was categorized as high (proportion of days covered [PDC], ≥90%; n?=?32?089), intermediate (PDC, 80%-89%; n?=?10?197) and low (PDC, <80%; n?=?9689). During a median 4.5?years (maximal 9?years) of follow-up in 51?975 CHB patients treated with entecavir, multivariable analyses revealed that the risk of mortality/transplantation was significantly greater in the low-adherers (adjusted hazard ratio [HR], 1.38; P?<.001) and intermediate-adherers (adjusted HR, 1.44; P?<.001) than the high-adherers (P for trend?
- Author(s)
- 이자연; 조송희; 김효정; 이한길; 고민정; 임영석
- Issued Date
- 2021
- Type
- Article
- Keyword
- Analysis; Entecavir; Hepatitis B; hepatitis B virus; hepatocellular carcinoma; Medical research; Medicine; Experimental; mortality; National health insurance; Patient compliance; Patient outcomes; proportion of days covered
- DOI
- 10.1111/jvh.13418
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/7034
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2451132906&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,High%20level%20of%20medication%20adherence%20is%20required%20to%20lower%20mortality%20in%20patients%20with%20chronic%20hepatitis%20B%20taking%20entecavir:%20A%20nationwide%20cohort%20study&offset=0&pcAvailability=true
- Publisher
- JOURNAL OF VIRAL HEPATITIS
- Location
- 미국
- Language
- 영어
- ISSN
- 1352-0504
- Citation Volume
- 28
- Citation Number
- 2
- Citation Start Page
- 353
- Citation End Page
- 363
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