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Insulin Resistance Increases Serum Immunoglobulin E Sensitization in Premenopausal Women

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Abstract
Background: Although studies have shown that obesity is associated with aeroallergen sensitization (atopy), controversy still exists. We aimed to investigate the association between metabolic status, obesity, and atopy stratified by sex and menopausal status.

Methods: A total of 1,700 adults from the 2010 Korean National Health and Nutrition Examination Survey were classified into metabolically healthy nonobese (MHNO), metabolically unhealthy nonobese (MUNO), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO) by body mass index and insulin resistance. Atopy was defined as a positive response to at least one aeroallergen. Multiple regression analysis was used to evaluate the risk of immunoglobulin E (IgE) elevation or atopy in relation to the degree of metabolic abnormality and obesity.

Results: In premenopausal women, total IgE was positively correlated with obesity and insulin resistance. MUNO participants had a higher risk of having elevated total IgE compared to MHNO participants (odds ratio [OR], 2.271; 95% confidence interval [CI], 1.201 to 4.294), while MHO participants did not show a significant difference (OR, 1.435; 95% CI, 0.656 to 3.137) in premenopausal women. MUNO, but not MHO was also associated with atopy (OR, 2.157; 95% CI, 1.284 to 3.625). In men and postmenopausal women, there was no significant difference between metabolic status, obesity, and atopy among groups.

Conclusion: Increased insulin resistance is associated with total IgE and atopy in premenopausal women but not in postmenopausal women or men.
Author(s)
고은희백지연이승은한경도
Issued Date
2021
Type
Article
Keyword
Immunoglobulin EInsulin resistanceMetabolic syndromeObesity
DOI
10.4093/dmj.2019.0150
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7048
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_kiss_primary_3872617&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Insulin%20Resistance%20Increases%20Serum%20Immunoglobulin%20E%20Sensitization%20in%20Premenopausal%20Women&offset=0&pcAvailability=true
Publisher
DIABETES METABOLISM JOURNAL
Location
대한민국
Language
영어
ISSN
2233-6079
Citation Volume
45
Citation Number
2
Citation Start Page
175
Citation End Page
182
Appears in Collections:
Medicine > Medicine
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