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Protocol for a Korean Multicenter Prospective Cohort Study of Active Surveillance or Surgery (KoMPASS) in Papillary Thyroid Microcarcinoma

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Abstract
Background: A Korean Multicenter Prospective cohort study of Active Surveillance or Surgery (KoMPASS) for papillary thyroid microcarcinomas (PTMCs) has been initiated. The aim is to compare clinical outcomes between active surveillance (AS) and an immediate lobectomy for low-risk PTMCs. We here outline the detailed protocol for this study.

Methods: Adult patients with a cytopathologically confirmed PTMC sized 6.0 to 10.0 mm by ultrasound (US) will be included. Patients will be excluded if they have a suspicious extra-thyroidal extension or metastasis of a PTMC or multiple thyroid nodules or other thyroid diseases which require a total thyroidectomy. Printed material describing the prognosis of PTMCs, and the pros and cons of each management option, will be provided to eligible patients to select their preferred intervention. For the AS group, thyroid US, thyroid function, and quality of life (QoL) parameters will be monitored every 6 months during the first year, and then annually thereafter. Disease progression will be defined as a >= 3 mm increase in maximal diameter of a PTMC, or the development of new thyroid cancers or metastases. If progression is detected, patients should undergo appropriate surgery. For the lobectomy group, a lobectomy with prophylactic central neck dissection will be done within 6 months. After initial surgery, thyroid US, thyroid function, serum thyroglobulin (Tg), anti-Tg antibody, and QoL parameters will be monitored every 6 months during the first year and annually thereafter. Disease progression will be defined in these cases as the development of new thyroid cancers or metastases.

Conclusion: KoMPASS findings will help to confirm the role of AS, and develop individualized management strategies, for low-risk PTMCs.
Author(s)
강예은강호철김민희김보현김선욱김원배문재훈송민호이용상이창윤임동준전민지조선욱
Issued Date
2021
Type
Article
Keyword
Active surveillanceCohort studiesComparative studyThyroid cancerpapillaryWatchful waiting
DOI
10.3803/EnM.2020.890
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7049
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_kiss_primary_3882159&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Protocol%20for%20a%20Korean%20Multicenter%20Prospective%20Cohort%20Study%20of%20Active%20Surveillance%20or%20Surgery%20(KoMPASS)%20in%20Papillary%20Thyroid%20Microcarcinoma&offset=0&pcAvailability=true
Publisher
ENDOCRINOLOGY AND METABOLISM
Location
대한민국
Language
한국어
ISSN
2093-596X
Citation Volume
36
Citation Number
2
Citation Start Page
359
Citation End Page
364
Appears in Collections:
Medicine > Medicine
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