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Statin/ezetimibe combination therapy vs statin monotherapy for carotid atherosclerotic plaque inflammation

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Abstract
It remains uncertain whether statin/ezetimibe combination therapy serves as a useful and equivalent alternative to statin monotherapy for reducing atherosclerotic plaque inflammation. The aim of the present study was to compare the effects of statin/ezetimibe combination therapy and statin monotherapy on carotid atherosclerotic plaque inflammation using F-18-fluorodeoxyglucose ((18)FDG) positron emission tomography (PET)/computed tomography (CT) imaging. Data were pooled from 2 clinical trials that used serial (18)FDG PET/CT examination to investigate the effects of cholesterol-lowering therapy on carotid atherosclerotic plaque inflammation. The primary outcome was the percent change in the target-to-background ratio (TBR) of the index vessel in the most diseased segment (MDS) at 6-month follow-up. Baseline characteristics were largely similar between the 2 groups. At the 6-month follow-up, the MDS TBR of the index vessel significantly decreased in both groups. The percent change in the MDS TBR of the index vessel (primary outcome) did not differ significantly between the 2 groups (-8.41 +/- 15.9% vs -8.08 +/- 17.0%, respectively, P = .936). Likewise, the percent change in the whole vessel TBR of the index vessel did not differ significantly between the 2 groups. There were significant decreases in total and LDL cholesterol levels in both groups at follow-up (P < .001). There were no significant correlations between the percent changes in MDS TBR of the index vessel, changes in the lipid, and high-sensitive C-reactive protein levels. The reduction in carotid atherosclerotic plaque inflammation by statin/ezetimibe combination therapy was equivalent to that by the statin monotherapy.
Author(s)
김도훈김현지문대혁성창환신언우오민영이승환이지성이철환이필형
Issued Date
2021
Type
Article
Keyword
3400Abridged Index MedicusAcute Coronary Syndrome - bloodAcute Coronary Syndrome - drug therapyAcute Coronary Syndrome - immunologyAgedC-Reactive Protein - analysisCarotid Arteries - diagnostic imagingCarotid Arteries - drug effectsCarotid Arteries - immunologyCarotid Artery Diseases - bloodCarotid Artery Diseases - complicationsCarotid Artery Diseases - drug therapyCarotid Artery Diseases - immunologyCholesterolLDL - bloodClinical Trials as TopicDatasets as TopicezetimibeEzetimibeSimvastatin Drug Combination - administration &amp; dosageFemaleFollow-Up StudiesHumansHydroxymethylglutaryl-CoA Reductase Inhibitors -administration &amp; dosageInflammation - complicationsInflammation - drug therapyInflammation - immunologyMaleMiddle AgedObservational Studyplaque inflammationPlaqueAtherosclerotic - bloodPlaqueAtherosclerotic - complicationsPlaqueAtherosclerotic - drug therapyPlaqueAtherosclerotic - immunologypositron emission tomographyRosuvastatin Calcium - administration &amp; dosageSimvastatin - administration &amp; dosagestatin
DOI
10.1097/MD.0000000000025114
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7050
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7969286&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Statin%2Fezetimibe%20combination%20therapy%20vs%20statin%20monotherapy%20for%20carotid%20atherosclerotic%20plaque%20inflammation&amp;offset=0&amp;pcAvailability=true
Publisher
MEDICINE
Location
미국
Language
한국어
ISSN
0025-7974
Citation Volume
100
Citation Number
10
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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