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Long-term clinical course and outcome in patients with primary Sjogren syndrome-associated interstitial lung disease

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Abstract
Interstitial lung disease (ILD) is the most common lung manifestation in patients with Sjogren syndrome (SJS) and is associated with poor outcomes. This study aimed to investigate the long-term clinical course and prognostic factors in patients with SJS-ILD. Clinical data and high-resolution computed tomography (HRCT) images of 62 patients with primary SJS-ILD were retrospectively analyzed (biopsy-proven cases, n=16). The mean patient age was 59.8 years; 83.9% of the patients were females, and 38.7% showed a usual interstitial pneumonia (UIP) pattern on HRCT. The median follow-up period was 61.5 months. During follow-up, 15 patients (24.2%) died, 7 (11.3%) experienced acute exacerbation (AE), and 27 (43.5%) progressed. The 1-, 3- and 5-year survival rates were 93.5%, 85.8%, and 81.1%, respectively. Age (hazard ratio [HR]: 1.158, P=0.003), C-reactive protein (CRP) level (HR: 1.212, P=0.045), FVC (HR: 0.902, P=0.005), and a UIP pattern on HRCT (HR: 4.580, P=0.029) were significant prognostic factors in multivariable Cox analysis. In conclusion, death, AE, and ILD progression occurred in 25%, 10%, and 50% of the patients with SJS-ILD, respectively. Older age, higher CRP level, lower FVC, and a UIP pattern on HRCT indicated poor prognosis.
Author(s)
송진우Ho Jeong KimJooae ChoeYun Jae Kim
Issued Date
2021
Type
Article
Keyword
BiopsyC-reactive proteinComputed tomographyLung diseasesMedical prognosisRespiratory tract diseasesRisk factorsSjogren's syndrome
DOI
10.1038/s41598-021-92024-2
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7058
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_ba4f33c0695a495788d04471b2377d4a&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Long-term%20clinical%20course%20and%20outcome%20in%20patients%20with%20primary%20Sjogren%20syndrome-associated%20interstitial%20lung%20disease&offset=0&pcAvailability=true
Publisher
SCIENTIFIC REPORTS
Location
영국
Language
영어
ISSN
2045-2322
Citation Volume
11
Citation Number
1
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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