The c-Abl inhibitor, radotinib induces apoptosis in multiple myeloma cells via mitochondrial?dependent pathway
- Abstract
- In conclusion, radotinib may play an important role as a candidate agent ornchemosensitizer for the treatment of MM.
- Issued Date
- 2021
- Type
- Article
- Keyword
- Abl protein; Animal models; Annexin V; Antitumor agents; Apoptosis; Bax protein; Bcl-2 protein; Bcl-x protein; BCR protein; c-Kit protein; Cancer; Caspase-3; Chronic myeloid leukemia; Cytochrome c; Cytosol; Fusion protein; Kinases; Membrane potential; Mitochondria; Multiple myeloma; Myeloid leukemia; Plasma cells; Platelet-derived growth factor; Poly(ADP-ribose) polymerase; Poly(ADP-ribose)Polymerase 1; Xenografts
- URI
- http://oak.ulsan.ac.kr/handle/2021.oak/7061
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_43d427a0131f4e40b71f116b3d316acb&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,The%20c-Abl%20inhibitor,%20%20radotinib%20induces%20apoptosis%20%20in%20multiple%20myeloma%20cells%20%20via%20mitochondrial%3Fdependent%20%20pathway&offset=0&pcAvailability=true
- Publisher
- SCIENTIFIC REPORTS
- Location
- 영국
- Language
- 영어
- ISSN
- 2045-2322
- Citation Volume
- 11
- Citation Number
- 1
- Citation Start Page
- 13198
- Citation End Page
- 13218
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