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The risk of Alzheimer's disease according to dynamic changes in metabolic health and obesity: a nationwide population-based cohort study

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Abstract
We evaluated the association of metabolic health and obesity phenotypes with the risk of Alzheimer's disease (AD). This study enrolled 136,847 elderly participants aged 60 or above from the Korean National Health Insurance System. At baseline examinations in 2009 and 2010, subjects were categorized into four groups: the metabolically healthy non-obese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy non-obese (MUNO), and metabolically unhealthy obese (MUO) groups. Based on the phenotypic transition after 2 years, the subjects were further categorized into 16 subgroups. They were followed from 2009 to 2015 to monitor for AD development.

The MHO phenotype protected subjects from AD, relative to the MHNO phenotype (HR, 0.73; 95% CI, 0.65-0.81). Among subjects initially classified as MHO, 41.8% remained MHO, with a significantly lower risk of AD compared with the stable MHNO group (HR, 0.62; 95% CI, 0.50-0.77). Among MUO subjects at baseline, those who changed phenotype to MUNO were at higher risk of AD (HR, 1.47; 95% CI, 1.28-1.70), and the transition to the MHO phenotype protected subjects from AD (HR, 0.62; 95% CI, 0.50-0.78).

The MHO phenotype conferred a decreased risk of AD. Maintenance or recovery of metabolic health might mitigate AD risk among obese individuals.
Author(s)
조윤경김예지김휘승박중열이우제이지우정창희
Issued Date
2021
Type
Article
Keyword
Alzheimer’s diseasemetabolic healthnationwide cohort studyobesityResearch Paper
DOI
10.18632/aging.203255
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7070
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8312469&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,The%20risk%20of%20Alzheimer%27s%20disease%20according%20to%20dynamic%20changes%20in%20metabolic%20health%20and%20obesity:%20a%20nationwide%20population-based%20cohort%20study&offset=0&pcAvailability=true
Publisher
AGING-US
Location
미국
Language
영어
ISSN
1945-4589
Citation Volume
13
Citation Number
13
Citation Start Page
16974
Citation End Page
16989
Appears in Collections:
Medicine > Medicine
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