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Incidence, Predictors, and Prognostic Impact of Immediate Improvement in Left Ventricular Systolic Function After Transcatheter Aortic Valve Implantation

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Abstract
Immediate improvement in left ventricular ejection fraction (LVEF) following transcatheter aortic valve implantation (TAVI) is common; however, data on the pattern and prognostic value of this improvement are limited. To evaluate the incidence, predictors, and clinical impact of immediate improvement in LVEF, we studied 694 consecutive patient who had underwent successful TAVI for severe aortic stenosis (AS) between March 2010 and December 2019. We defined immediate improvement of LVEF as an absolute increase of >= 5% in LVEF at post-procedure echocardiogram. The primary outcome was major adverse cardiac or cerebrovascular event (MACCE), defined as a composite of death from cardiovascular cause, myocardial infarction, stroke, or rehospitalization from cardiovascular cause. Among them, 160 patients showed immediate improvement in LVEF. The independent predictors of immediate LVEF improvement were absence of hypertension and baseline significant aortic regurgitation, and greater baseline LV mass index. Immediate improvement in LVEF was significantly associated with a lower risk of MACCE (adjusted hazard ratio, 0.48; 95% confidence interval, 0.28-0.81; p = 0.01). In conclusion, approximately one-fourth of patients with severe AS who underwent TAVI showed immediate improvement in LVEF during index hospitalization. Immediate LVEF recovery was associated with a lower risk of MACCE during follow-up. (C) 2021 Elsevier Inc. All rights reserved.
Author(s)
강도윤고의홍김대희김준범김호진박덕우박승정박한빛안정민이승아정영진주석중
Issued Date
2021
Type
Article
Keyword
Abridged Index Medicus
DOI
10.1016/j.amjcard.2021.04.037
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7085
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2541321779&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Incidence,%20Predictors,%20and%20Prognostic%20Impact%20of%20Immediate%20Improvement%20in%20Left%20Ventricular%20Systolic%20Function%20After%20Transcatheter%20Aortic%20Valve%20Implantation&offset=0&pcAvailability=true
Publisher
AMERICAN JOURNAL OF CARDIOLOGY
Location
미국
Language
영어
ISSN
0002-9149
Citation Volume
152
Citation Number
1
Citation Start Page
99
Citation End Page
105
Appears in Collections:
Medicine > Medicine
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